Journal: Drug Invention Today

Article Id: JPRS-P col-00003513
Title: Lupeol supplementation attenuates overexpression of sterol regulatory element-binding protein in hepatocytes: An experimental study
Category: Pharmaceutics
Section: Research Article
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    Background: Lupeol, a natural herbal drug, is abundant in edible vegetables, fruits, and also medicinal plants. It has been shown to reduce hyperglycemia and hyperinsulinemia in experimental mice model. Despite the effect of lupeol on sterol regulatory element, binding protein (SREBP-1c) in hepatocytes is not known. Objectives: The study aimed to identify the effects of lupeol on SREBP-1c protein expression in liver tissue of type 2 diabetic rats. Methods: Lupeol was administered orally to type 2 diabetic rats (25 mg/kg body weight) for 30 days. After the treatment period, animals were anesthetized and the liver from control and experimental animals was dissected out and used for the protein expression of SREBP-1c. Results: In type 2 diabetic animals, the protein expression of SREBP-1c was found to be elevated in high-fat diet-induced type 2 diabetic rats when compared with control. The lupeol administration to diabetic rats reduced the SREBP-1c protein expression due to its antioxidant potentials. Conclusion: Our present finding indicates that the antidiabetic activity of lupeol in the liver is mediated through the attenuation of SREBP-1c protein.

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    Author(s) Name:

    V. Jayavabhushana1 , V. Vishnupriya1 , R. Ponnulakshmi 2 , R. Gayathri 1 , B. Shyamaladevi 1 , K. Madhan1 , J. Selvaraj1 *

    Affiliation(s) Name:

    1 Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Central Research Laboratory, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. J. Selvaraj, Assistant Professor in Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai - 600 077, India.

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    Author:

    V. Jayavabhushana1 , V. Vishnupriya1 , R. Ponnulakshmi 2 , R. Gayathri 1 , B. Shyamaladevi 1 , K. Madhan1 , J. Selvaraj1 *

    Title:Lupeol supplementation attenuates overexpression of sterol regulatory element-binding protein in hepatocytes: An experimental study
    Journal:Drug Invention Today
    Vol(issue):12 (May)
    Year:2019
    Page No: (866-869)
  • Experimental Methods Keywords

    Methodology:Western Blot Analysis
    Research Materials:Lupeol

Keywords

High-fat diet Lupeol Sterol regulatory element-binding protein Type 2 diabetes

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