Journal: Drug Invention Today

Article Id: JPRS-P col-00003514
Title: Effect of beta-sitosterol on glycogen metabolic enzyme in high-fat fed diabetic model
Category: Pharmacology
Section: Research Article
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    Background: Diabetes mellitus (DM) is a chronic metabolic disorder characterized by insufficient insulin secretion or resistance to insulin secretion or resistance to insulin action or both. Management of DM with natural antioxidants grabs great interest of research due to its beneficiary effects. Hence, in our study, we focused to study beta-sitosterol (BS), a plant sterol found in the wheat germ, Ce, flax seeds, peanuts, soybean, and variety of medicinal plants. It has antidiabetic, hypolipedemic, anticancer, antiarthritic, and hypoprotective role. In the present study, we elucidated the effects of BS on key enzymes of carbohydrates metabolism, which has been not yet studied clearly. Objectives: The objectives of this study were to study the effects of BS on glycogen metabolic enzymes in hepatic tissue of type 2 diabetic rats by spectrometry analysis. Methodology: BS was administered orally to type-2 diabetic rats (25 mg/kg body weight) for a period of 30 days. After the treatment period, animals were anesthetized and liver from control and experimental rats dissected out and the used for the studied. Results: There was a marked decrease observed in the levels of glycogen metabolic enzymes such as glycogen phosphorylase, glycogen synthase, and glycogen concentration in the liver of the type-2 diabetic rats. However, BS treatment efficiently increased the level of antioxidant enzymes compared to diabetic group. Metformin showed a similar pattern to that of BS. Conclusion: The present finding concluded that the BS regulates glycogen metabolic enzymes in the liver, and hence, it can be used for the management of type -2 diabetes as a natural compound.

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    Author(s) Name:

    M. Kavya Shree1 , V. Vishnupriya1 , R. Ponnulakshmi 2 , R. Gayathri 1 , K. Madhan1 , B. Shyamaladevi 1 , J. Selvaraj 1 *

    Affiliation(s) Name:

    1 Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Central Research Laboratory, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. J. Selvaraj, Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai - 600 077, India.

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    Author:

    M. Kavya Shree1 , V. Vishnupriya1 , R. Ponnulakshmi 2 , R. Gayathri 1 , K. Madhan1 , B. Shyamaladevi 1 , J. Selvaraj 1 *

    Title:Effect of beta-sitosterol on glycogen metabolic enzyme in high-fat fed diabetic model
    Journal:Drug Invention Today
    Vol(issue):12 (May)
    Year:2019
    Page No: (870-872)
  • Experimental Methods Keywords

    Methodology:glycogen synthase enzyme activity,Glycogen Phosphorylase,Glycogen and Glycogen Metabolic Enzymes
    Research Materials:Beta-sitosterol

Keywords

Beta-sitosterol High fat and high sucrose Type-2 diabetes

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