Journal: Drug Invention Today

Article Id: JPRS-P col-00003515
Title: Effect of lupeol on enzymatic and non-enzymatic antioxidants in type-2 diabetic adult male Wistar rats
Category: Pharmacology
Section: Research Article
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    Background: Lupeol is a pharmacologically active triterpenoid found in mango and variety of medicinal plants including Acacia visco and Abronia villosa. It is also found in dandelion coffee. Many scientific studies have shown that lupeol possesses many beneficial pharmacological activities including anti-inflammatory, antioxidant, and antihyperglycemic activity. Biomarkers for oxidative damage to DNA, lipids, and proteins are also supporting the concept of increased oxidative stress in diabetes and diabetic nephropathy. In the present study, we elucidated the antioxidant potential of lupeol by analyzing the enzymic and non-enzymic antioxidant in the liver of high-fat diet and sucrose-induced type-2 diabetic rats. Objectives: The study aimed to identify the effects of lupeol on enzymic antioxidants superoxide dismutase (SOD), catalase (CAT), and non-enzymic antioxidant (Vitamin C) in the liver of high-fat diet and sucrose-induced type-2 diabetic adult male rats. Methodology: Lupeol was administered orally to type-2 diabetic rats (25 mg/kg body weight) for a period of 30 days. After the treatment period, animals were anesthetized and liver from control and experimental rats dissected out and the used for the studied. Results: There was a marked decrease observed in the levels of antioxidant enzymes (SOD, CAT, and Vitamin C) in the liver of the type-2 diabetic rats. However, lupeol treatment efficiently increased the level of antioxidant enzymes compared to diabetic group. Metformin showed a similar pattern to that of lupeol. Conclusion: The present finding concluded that the lupeol regulates antioxidant enzymes, and hence, it can be used for the management of type-2 diabetes as a natural compound.

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    Author(s) Name:

    G. Pushpanjali 1 , V. Vishnupriya1 , R. Ponnulakshmi 2 , R. Gayathri 1 , K. Madhan1 , B. Shyamaladevi 1 , J. Selvaraj 1 *

    Affiliation(s) Name:

    1 Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Central Research Laboratory, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. J. Selvaraj, Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai - 600 077, Tamil Nadu, India.

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    Author:

    G. Pushpanjali 1 , V. Vishnupriya1 , R. Ponnulakshmi 2 , R. Gayathri 1 , K. Madhan1 , B. Shyamaladevi 1 , J. Selvaraj 1 *

    Title:Effect of lupeol on enzymatic and non-enzymatic antioxidants in type-2 diabetic adult male Wistar rats
    Journal:Drug Invention Today
    Vol(issue):12 (May)
    Year:2019
    Page No: (873-876)
  • Experimental Methods Keywords

    Methodology:uperoxide dismutase, Type-2 diabetes
    Research Materials: Lupeol

Keywords

Catalase High fat and high sucrose Lupeol Superoxide dismutase Type-2 diabetes

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