Journal: Drug Invention Today

Article Id: JPRS-P col-00003524
Title: Effects of beta-sitosterol on inflammatory cytokines in high-fat diet-fed type-2 diabetic rats
Category: Pharmacology
Section: Research Article
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    Background: β-sitosterol is a naturally occurring plant sterol, ubiquitously found in many plants. It has been shown to reduce hyperglycemia and hyperinsulinemia in experimental mice model. Despite the effect of β-sitosterol on inflammatory cytokines in high-fat diet (HFD)-fed type-2 diabetic rats is not known. Objectives: The study aimed to identify the effects of beta-sitosterol on inflammatory cytokines in HFD-fed type-2 diabetic rats. Methodology: β-sitosterol was administered orally to type-2 diabetic rats (20 mg/kg body weight) for a period of 30 days. After the treatment period, animals were anesthetized and liver from control and experimental animals was dissected out and the concentration of tumor necrosis factor (TNF)-α and interleukin (IL)-1 in serum sample of diabetes rats was determined by the use of a commercial enzyme-linked immunosorbent assay kit. Results: In type-2 diabetic animals, the TNF-α and IL-1c were found to be elevated in HFD-induced type-2 diabetic rats when compared with control. The β-sitosterol treatment significantly reduced the levels of TNF-α and IL-1 in type-2 diabetic rats. Conclusion: Our present finding indicates that the antidiabetic activity of β-sitosterol on inflammatory cytokines in HFD-fed type-2 diabetic rats.

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    Author(s) Name:

    S. Bharanishankar1 , V. Vishnupriya1 , R. Ponnulakshmi 2 , R. Gayathri 1 , K. Madhan1 , B. Shyamaladevi 1 , J. Selvaraj 1 *

    Affiliation(s) Name:

    1 Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Central Research Laboratory, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India.

    *Corresponding author: Dr. J. Selvaraj, Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai - 600 077, Tamil Nadu, India.

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    Author:

    S. Bharanishankar1 , V. Vishnupriya1 , R. Ponnulakshmi 2 , R. Gayathri 1 , K. Madhan1 , B. Shyamaladevi 1 , J. Selvaraj 1 *

    Title:Effects of beta-sitosterol on inflammatory cytokines in high-fat diet-fed type-2 diabetic rats
    Journal:Drug Invention Today
    Vol(issue):12 (May)
    Year:2019
    Page No: (906-909)
  • Experimental Methods Keywords

    Methodology:Interleukin-1, Tumor necrosis factor-alpha, Type-2 diabetes, β-Sitosterol
    Research Materials:High-fat diet

Keywords

High-fat diet Interleukin-1 Tumor necrosis factor-alpha Type-2 diabetes β-Sitosterol

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