Journal: Drug Invention Today
Title: Remedial effects of β-sitosterol in high-fat diet-induced oxidative stress in experimental rats
Category: Pharmaceutics
Section: Research Article
- Abstract
- Audio Abstract
- Authors
- Pdf File
- Citation
- My Reference
- Methodology
-
Abstract
Background: β-sitosterol is a naturally occurring plant sterol, ubiquitously found in many plants. It has been shown to reduce hyperglycemia and hyperinsulinemia in experimental mice model. Despite the effect of β-sitosterol on oxidative stress in high-fat diet (HFD) fed type-2 diabetic rats is not known. Objectives: The study aimed to identify the remedial effects of β-sitosterol in HFD-induced oxidative stress in experimental rats. Methodology: Adult male albino rats of Wistar strain 150–180 days old with 180–200 g body weight were randomly divided into four groups of six rats each: Group I – normal rats; Group II – type 2 diabetic rats; Group III – type 2 diabetic rat treated with β-sitosterol (20 mg/kg b.wt/day), orally for 30 days; Group IV – type 2 diabetic rats treated with metformin (50 mg/kg, b.wt/day orally for 30 days). After the treatment period, animals were anesthetized and the liver from control and experimental animals was immediately dissected and used for the further study. Results: In type 2 diabetic animals, compared to control, the hydrogen peroxide (H2 O2 ), hydroxyl radical (OH*), and lipid peroxidation (LPO) in the liver of diabetic rats were significantly raised. β-sitosterol notably brought down the rise in H2 O2 , OH*, and LPO. Conclusion: Our present finding indicates that the antidiabetic activity of β-sitosterol on oxidative stress in HFD fed type-2 diabetic rats.
-
Abstract Audio
No Audio file found
About the authors and Affiliations
Author(s) Name: A. Akilarooran1 , V. Vishnupriya1 , R. Ponnulakshmi 2 , R. Gayathri 1 , K. Madhan1 , B. Shyamaladevi 1 , J. Selvaraj 1 *
Affiliation(s) Name: 1 Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,
2 Department of Central Research Laboratory, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India
*Corresponding author: Dr. J. Selvaraj, Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, Tamil Nadu, India.
-
View Article File in pdf format.
Article File
-
View Article Citation Here.
0 View More -
How to Cite my Article.
Author: A. Akilarooran1 , V. Vishnupriya1 , R. Ponnulakshmi 2 , R. Gayathri 1 , K. Madhan1 , B. Shyamaladevi 1 , J. Selvaraj 1 *
Title: Remedial effects of β-sitosterol in high-fat diet-induced oxidative stress in experimental rats Journal: Drug Invention Today Vol(issue): 12 (May) Year: 2019 Page No: (910-913) -
Experimental Methods Keywords
Methodology: Oxidative stress, Type 2 diabetes, β-sitosterol Research Materials: High-fat diet
Keywords
Our Services
- Mucoadhesive oral in situ gel of itraconazole using pH-sensitive polymers: Preparation, and in vitro characterization, release and rheology study
- Pharmacognostic standardization and high-performance thin-layer chromatography fingerprint profile of Lagenaria siceraria (Molina) Standl. fruits
- Phytochemical and pharmacological potential of Artemisia absinthium Linn. and Artemisia asiatica Nakai : A Review
- Antibacterial activity of different endodontic sealers: An in vitro evaluation
- Effectiveness of good behavior game on oral health among children - A randomized trial
- Effect of music on academic performance of college students
- Medicinal uses of banana (Musa paradisiaca)
- Extraction of Betacyanin from Red Beet root (Beta vulgaris L.) and to evaluate its antioxidant potential antioxidant potential
- Biodegradable plastic production from corn starch
- Standardization of Nandhi Mezhugu, a poly herbomineral Siddha formulation
- The role of toponymic objects in the system of settlement and reconstruction of landscapes in the Pre-Volga Region of the Republic of Tatarstan
- Estimation of Tizanidine HCl by UV-Spectrophotometric Method
- Formulation and evaluation of topical gel of diclofenac sodium using different polymers
- Antidiabetic activity of insulin plant (Costus igneus) leaf extract in diabetic rats
- Effects of lupeol on insulin receptor and glucose transporter-4 in cardiac tissue of Type-2 diabetic rats
- Simultaneous Spectrophotometric Estimation of Paracetamol and Aceclofenac in Combined Tablet Formulations using Hydrotropic Solubilization Technique
- Benzoic acid, one of the major components of aqueous bark extract of Terminalia arjuna protects against Copper-Ascorbate induced oxidative stress in human placental mitochondria through antioxidant m
- Formulation and Evaluation of Sildenafil Citrate Fast Dissolving Tablets Using Crospovidone and Croscarmellose Sodium Superdisintegrants
- Formulation and evaluation of solid dispersions of valsartan for dissolution rate enhancement
- Ethosomes: A novel tool for drug delivery through the skin
- Validation of Uv Spectrophotometric method for estimation of Levocetirizine Dihydrochloride in bulk and pharmaceutical formulation
- In silico and in vivo approach to identify the antidiabetic activity of lupeol
- Fomulation and Evaluation of Taste Masked Spherical Agglomerates of Telmisartan
- Comparative Study of Ionotropic Gelation Technique To Entrap Diltiazem HCl In Mucoadhesive Microparticulate System.
- Preparation and Characterization of Pharmaceutical Grade Chitosan And Hydrated Chitosan Gums for Topical Preparations
- Aspergillus Derived Silver Nano Particles as a Potent Antibacterial Agent and Identification of Linked Proteins
- Assortment of vital nutrients for enhancement of Cyclodextrin glycosyltransferase produced by Bacillus amyloliquefaciens KST5: A Plackett-Burman design approach
- In vitro antibacterial activity of essential oils of selected herbals against isolates from HIV/AIDS patients
- Novel Controlled Gastroretentive Drug Delivery Systems: A Review
- Antiulcer activity of aqueous suspension of Saraca indica flower against gastric ulcers in albino rats