Journal: Drug Invention Today

Article Id: JPRS-P col-00003525
Title: Remedial effects of β-sitosterol in high-fat diet-induced oxidative stress in experimental rats
Category: Pharmaceutics
Section: Research Article
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    Background: β-sitosterol is a naturally occurring plant sterol, ubiquitously found in many plants. It has been shown to reduce hyperglycemia and hyperinsulinemia in experimental mice model. Despite the effect of β-sitosterol on oxidative stress in high-fat diet (HFD) fed type-2 diabetic rats is not known. Objectives: The study aimed to identify the remedial effects of β-sitosterol in HFD-induced oxidative stress in experimental rats. Methodology: Adult male albino rats of Wistar strain 150–180 days old with 180–200 g body weight were randomly divided into four groups of six rats each: Group I – normal rats; Group II – type 2 diabetic rats; Group III – type 2 diabetic rat treated with β-sitosterol (20 mg/kg b.wt/day), orally for 30 days; Group IV – type 2 diabetic rats treated with metformin (50 mg/kg, b.wt/day orally for 30 days). After the treatment period, animals were anesthetized and the liver from control and experimental animals was immediately dissected and used for the further study. Results: In type 2 diabetic animals, compared to control, the hydrogen peroxide (H2 O2 ), hydroxyl radical (OH*), and lipid peroxidation (LPO) in the liver of diabetic rats were significantly raised. β-sitosterol notably brought down the rise in H2 O2 , OH*, and LPO. Conclusion: Our present finding indicates that the antidiabetic activity of β-sitosterol on oxidative stress in HFD fed type-2 diabetic rats.

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    Author(s) Name:

    A. Akilarooran1 , V. Vishnupriya1 , R. Ponnulakshmi 2 , R. Gayathri 1 , K. Madhan1 , B. Shyamaladevi 1 , J. Selvaraj 1 *

    Affiliation(s) Name:

    1 Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Central Research Laboratory, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. J. Selvaraj, Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, Tamil Nadu, India.

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    Author:

    A. Akilarooran1 , V. Vishnupriya1 , R. Ponnulakshmi 2 , R. Gayathri 1 , K. Madhan1 , B. Shyamaladevi 1 , J. Selvaraj 1 *

    Title:Remedial effects of β-sitosterol in high-fat diet-induced oxidative stress in experimental rats
    Journal:Drug Invention Today
    Vol(issue):12 (May)
    Year:2019
    Page No: (910-913)
  • Experimental Methods Keywords

    Methodology:Oxidative stress, Type 2 diabetes, β-sitosterol
    Research Materials:High-fat diet

Keywords

High-fat diet Oxidative stress Type 2 diabetes β-sitosterol

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