Journal: Drug Invention Today

Article Id: JPRS-P col-00003527
Title: Effects of β-sitosterol on serum, adiponectin, and leptin levels in high-fat diet and fructose-induced diabetic rats
Category: Pharmaceutics
Section: Research Article
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    Background: β-sitosterol is a naturally occurring plant sterol, ubiquitously found in many plants. It has been shown to reduce hyperglycemia and hyperinsulinemia in experimental mice model. Despite, the effect of β-sitosterol on serum adiponectin and leptin levels in high-fat diet (HFD) and fructose-induced diabetic rats is not known. Objectives: The study aimed to identify the effects of beta-sitosterol on serum adiponectin and leptin levels in HFD and fructose-induced diabetic rats. Materials and Methods: β-sitosterol was administered orally to Type-2 diabetic rats (20 mg/kg body weight) for a period of 30 days. After the treatment period, animals were anesthetized and the liver from control and experimental animals was dissected out, and the concentration of adiponectin and leptin in serum sample of diabetes rats was determined by the use of a commercial ELISA Kit. Results: In Type-2 diabetic animals, decrease in the level of adiponectin and a concomitant increase in the leptin levels were observed in Type-2 diabetic experimental rats, whereas β-sitosterol treatment significantly restored the altered levels in type- 2 diabetic experimental rats. Conclusion: Our present finding indicates that β-sitosterol plays a significant role in the regulation of circulating adiponectin and leptin levels in HFD and fructose-induced Type-2 diabetic rats.

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    Author(s) Name:

    R. Theiva Chandran1 , V. Vishnupriya1 , R. Ponnulakshmi 2 , R. Gayathri 1 , K. Madhan1 , B. Shyamaladevi 1 , J. Selvaraj 1 *

    Affiliation(s) Name:

    1 Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Central Research Laboratory, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. J. Selvaraj, Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, Tamil Nadu, India.

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    Author:

    R. Theiva Chandran1 , V. Vishnupriya1 , R. Ponnulakshmi 2 , R. Gayathri 1 , K. Madhan1 , B. Shyamaladevi 1 , J. Selvaraj 1 *

    Title:Effects of β-sitosterol on serum, adiponectin, and leptin levels in high-fat diet and fructose-induced diabetic rats
    Journal:Drug Invention Today
    Vol(issue):12 (May)
    Year:2019
    Page No: (917-919)
  • Experimental Methods Keywords

    Methodology:Estimation of Serum Adiponectin, Estimation of Serum Leptin
    Research Materials:Adiponectin, Fructose

Keywords

Adiponectin Fructose High-fat diet Leptin Type-2 diabetes β-sitosterol

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