Journal: Inter. J. of Chemical and Analytical Science
Title: Simultaneous Spectrophotometric Estimation of Paracetamol and Aceclofenac in Combined Tablet Formulations using Hydrotropic Solubilization Technique
Category: Analytical Chemistry
Section: Research Article
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Abstract
Quantitative estimation of poorly water-soluble drugs involves the use of organic solvents. Major drawbacks of organic solvents include high cost, toxicity, volatility and pollution. In the present investigation, the hydrotropic solubilization is employed to enhance the aqueous solubilities of poorly water-soluble drugs, paracetamol and aceclofenac in two-component tablet formulation for simultaneous spectrophotometric determination. Three simple, precise, accurate and economical procedures employed are simultaneous equation method, absorbance ratio method and multicomponent mode of analysis. All the methods utilize the combined hydrotropic blend of 20% urea solution and 20% sodium citrate solution precluding the use of organic solvent. In the mixed hydrotropic solution, paracetamol and aceclofenac shows maximum absorption at 245 nm and 274 nm, respectively and isoabsorptive point observed was 262 nm. The hydrotropic agents show no absorbance above 237 nm. The hydrotropicagents as well as tablet excipients in formulation did not interfere in the analysis. The results of analysis have been validated statistically.
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About the authors and Affiliations
Author(s) Name: Gajanand Engla1, R.K. Maheshwari2, Megha Agrawal1*, Archana Agrawal2
Affiliation(s) Name: 1GRY Institute of Pharmacy, Borawan, (Khargone), (M.P.)
2Department of Pharmaceutics, Shri G.S.Institute of Technology and Science, Indore (M.P.)*Corresponding author.
Megha Agrawal
GRY Institute of Pharmacy, Borawan, (Khargone), (M.P.)
Received on: 12-03-2010; Revised on: 14-04-2010; Accepted on:22-05-2010-
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Author: Gajanand Engla1, R.K. Maheshwari2, Megha Agrawal1*, Archana Agrawal2
Title: Simultaneous Spectrophotometric Estimation of Paracetamol and Aceclofenac in Combined Tablet Formulations using Hydrotropic Solubilization Technique Journal: Inter. J. of Chemical and Analytical Science Vol(issue): 1 (June) Year: 2010 Page No: (118-120) -
Experimental Methods Keywords
Methodology: Spectrophotometry. Research Materials: Paracetamol and Aceclofenac
Keywords
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