Journal: Drug Invention Today

Article Id: JPRS-P col-00003535
Title: Study of some biochemical, hematological parameters, insulin resistance, and clinical markers for β-thalassemia patients in Al-Najaf Al-Ashraf Governorate
Category: Pharmacology
Section: Research Article
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    Background: Thalassemia is considered as an inherited autosomal recessive blood disease synthesis rate of the globin chains that make up hemoglobin (Hb) is reduced due to genetic defect. This reduction leads to form abnormal Hb which, in turn, causes the anemia, and this considers as the main characteristic symptoms of thalassemia. Materials and Methods: The number of patients with thalassemia that included in this study was 60 participants. The range of patient’s age was between 5 and 12 years. These participants were diagnosed as thalassemic patients in thalassemia central at “Al-Zahra’a Teaching Hospital” in Najaf Governorate-Iraq. All these patients had β-thalassemia major as recorded to exclude elevated ferritin. These patients had treated blood transfusion and had a negative serum, C-reactive protein (CRP) was determined by the selection of 30 healthy children as a control group. Serum iron (S. iron) and total iron-binding capacity (TIBC) were diagnosed in spectrophotometrically. Results: Thalassemic patients showed a significant increase (P < 0.05) in all iron indices in comparison with the control group except TIBC were decreased significant (P < 0.05). Insulin resistance (IR) is high by four methods that include determination quantitative insulin check index (QUIKI), homeostasis model assessment (HOMA), fasting insulin (FI), and McAuley (McA). IR found in 17 (28.3%), 27 (45%), 38 (63.3%), and 40 (66.7%) out of the 60 beta-thalassemia by FI, McA, QUICKi, and HOMA, respectively. The aim of the present study was to investigate the possible relationships between insulin, interleukin-8 (IL-8), CRP, ferritin, S. iron, TIBC, body mass index levels, and noninsulin-dependent diabetes mellitus (NIDDM) with IR results also show that the mean value of serum insulin was significantly high (P < 0.05) in beta-thalassemia patients group. Also Serum IL-8 mean value was high in beta-thalassemia patients group. Conclusions: The current study concludes significant elevations in serum insulin, ferritin, S. iron, and HbA1C with a nonsignificant decline CRP in β-thalassemia and NIDDM patients in comparison with normal subjects due to metabolic effect of β-thalassemia and diabetes itself.

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    Author(s) Name:

    Zeyad Swadi Obead Al-Essawi 1 , Hussein Hazim Al-Ghanimi 1 *, Dheyaa Shakir Mashrea2 , Hussein Mahdi Kadhim3 , Raed A. Al-Mihyawi 4 , Muamer Ehsan Shakir Alshalah3

    Affiliation(s) Name:

    1 Department of Pathological Analysis Techniques, Al-Zahraw University College, Karbala, Iraq,

    2 Department of Dentistry, Al-Zahraw University College, Karbala, Iraq,

    3 University of Ahel albeit, College of pharmacy, Karbala, Iraq, 4 Mayorality of Baghdad, Baghdad, Iraq

    *Corresponding author: Hussein Hazim Al-Ghanimi, Department of Pathological Analysis Techniques, Al-Zahraw University College, Karbala, Iraq

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    Author:

    Zeyad Swadi Obead Al-Essawi 1 , Hussein Hazim Al-Ghanimi 1 *, Dheyaa Shakir Mashrea2 , Hussein Mahdi Kadhim3 , Raed A. Al-Mihyawi 4 , Muamer Ehsan Shakir Alshalah3

    Title:Study of some biochemical, hematological parameters, insulin resistance, and clinical markers for β-thalassemia patients in Al-Najaf Al-Ashraf Governorate
    Journal:Drug Invention Today
    Vol(issue):12 (May)
    Year:2019
    Page No: (943-947)
  • Experimental Methods Keywords

    Methodology:Beta-thalassemia, C-reactive protein, Insulin resistance, Interleukin-8
    Research Materials:patient’s age was between 5 and 12 years

Keywords

Beta-thalassemia C-reactive protein Insulin resistance Interleukin-8

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