Journal: Drug Invention Today

Article Id: JPRS-P col-00003546
Title: Antioxidant and free radical scavenging activity of Ocimum basilicum – An in vitro study
Category: Pharmaceutics
Section: Research Article
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    Aim: Antioxidants are man-made or natural substances that may prevent or delay some types of cell damage. They play an important role in inhibition and radical scavenging, thus providing protection against diseases. A great number of medicinal plants contain chemical compounds which possess antioxidant activities. Natural antioxidants are mainly phenolic compounds that may exist in all parts of the plants. Antioxidant potential of the ethanolic extract of Ocimum basilicum was studied using different in vitro free radical scavenging models such as 2, 2 Diphenyl-1-picryl hydrazyl radical (DPPH) and hydrogen peroxide. The DPPH results have been compared with the standard ascorbic acid. The extract showed good dose- dependent free radical scavenging property in both the models used in this study. Materials and Methods: The free radical scavenging activity of the ethanolic extract of O. basilicum was determined using DPPH using ultraviolet-spectrometry at 517 nm. The DPPH solution was prepared in 95% methanol. Conclusion: In vitro, antioxidant effects of O. basilicum were tested using DPPH and catalase method. The extract O. basilicum expressed the strongest antioxidant activity. The extracts of O. basilicum leaves showed good free radical scavenging activity. The broad range of antioxidant activity of this extract indicates the potential of the plant as a source of natural antioxidants with potential application to reduce oxidative stress and consequent health benefits. The plant may thus be exploited in the pharmaceutical and food industries. The study, therefore, not only reveals the spices as accessible reservoirs of natural antioxidants to be utilizes nutritionally and pharmaceutically but also very importantly, provides good scientific justification for increased domestication of these plants.

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    Author(s) Name:

    V. Lavanya1 , Dhanraj Ganapathy2 *, R. M. Visalakshi 2

    Affiliation(s) Name:

    1 Department of Prosthodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Prosthodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. Dhanraj Ganapathy, Department of Prosthodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, 162, Poonamallee High Road, Chennai - 600 077, Tamil Nadu, India

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    Author:

    V. Lavanya1 , Dhanraj Ganapathy2 *, R. M. Visalakshi 2

    Title:Antioxidant and free radical scavenging activity of Ocimum basilicum – An in vitro study
    Journal:Drug Invention Today
    Vol(issue):12 (May)
    Year:2019
    Page No: (1004-1007)
  • Experimental Methods Keywords

    Methodology:Antioxidant activity, Free Radical, Scavenging
    Research Materials:Ocimum basilicum

Keywords

2 2 Diphenyl-1-picrylhydrazyl radical Antioxidant activity Free Radical Scavenging Hydrogen peroxide Ocimum basilicum

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