Journal: Inter. J. of Chemical and Analytical Science

Article Id: JPRS-PC-0000355
Title: Synthesis and Anti-Inflammatory Activity of Some 5-Phenyl-1-(Acyl)-1, 2, 3, 4-Tetrazole.
Category: Pharmaceutical Chemistry
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  • Abstract

    A novel substituted pyrazole trifluoro methyl hexa hydro pyrimidinones (4a-g) have been prepared by Biginelli condensation of six substituted pyrazolealdehydes, ethyltrifluoroacetoacetate and urea using zinc chloride as catalyst. The structures of the synthesized compounds have been confirmed on the basis of spectral data. The newly synthesized compounds have been assayed invitro for antimicrobial activity and cardiotonic activity.

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    Author(s) Name:

    Radhika. Tummaa*, Naseeb basha. Shaikb, Pallavi.Kc and Dr. B. B. Gawalid

    Affiliation(s) Name:

    aDepartment of Pharmaceutical chemistry, G. Pulla reddy college of Pharmacy, Hyderabad- 500 028.A.P. India
    b,cDepartment of Pharmaceutics, G. Pulla reddy college of Pharmacy, Hyderabad- 500 028.A.P. India
    dDepartment of Chemistry, Scientist F, IICT, Hyderabad.A.P. India

    *Corresponding author.
    Radhika. Tumma
    aDepartment of Pharmaceutical chemistry, G. Pulla reddy college of
    Pharmacy, Hyderabad- 500 028


    Received on: 20-02-2010; Revised on: 16-03-2010; Accepted on:15-04-2010

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    Author:

    Radhika. Tummaa*, Naseeb basha. Shaikb, Pallavi.Kc and Dr. B. B. Gawalid

    Title:Synthesis and Anti-Inflammatory Activity of Some 5-Phenyl-1-(Acyl)-1, 2, 3, 4-Tetrazole.
    Journal:Inter. J. of Chemical and Analytical Science
    Vol(issue):1(6)
    Year:2010
    Page No: (127-129)
  • Experimental Methods Keywords

    Methodology:Synthesis and Anti-Inflammatory Activity
    Research Materials:Some 5-Phenyl-1-(Acyl)-1, 2, 3, 4-Tetrazole.

Keywords

Beginelli condensation 1 3 diphenylpyrazole-4-carboxaldehyde trifluoromethylhexahydro pyrimidinones antimicrobial and cardiotonic activity.

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