Journal: Drug Invention Today

Article Id: JPRS-P col-00003559
Title: Effectiveness of cyclooxygenase-2 inhibitors in the management of post-extraction pain
Category: Pharmaceutics
Section: Research Article
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    Aim: The aim of this study is to evaluate the effectiveness of cyclooxygenase-2 (COX-2) inhibitors in the management of post-extraction pain. Background: Dental pain is associated with fear and avoidance of dental treatment by many people. Extractions being one of the most common procedures in dentistry are associated with varying degrees of pre-operative and post-operative pain. Analgesics are medications that are used to alleviate pain. The analgesics are basically nonsteroidal anti-inflammatory drugs (NSAIDs) which have many subclasses such as salicylates, mefenamic acid, COX-1 and 2 inhibitors, preferential COX-2 inhibitors, and selective COX- 2 inhibitors. Their mechanism of action varies and also the adverse effects. Results: The Mann–Whitney U-test revealed that there existed no significant difference in the effectiveness between non-selective NSAIDs and selective COX-2 inhibitors in the management of post-extraction pain as P = 0.556 which is greater than 0.05. Conclusion: This study inferred equal effectiveness between COX-2 inhibitors and NSAIDs. However, COX-2 inhibitors induce lesser side effects and hence can be preferred in suitable clinical conditions.

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    Author(s) Name:

    P. Kalyani, Dhanraj Ganapathy*, R. M. Visalakshi

    Affiliation(s) Name:

    Department of Prosthodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. Dhanraj Ganapathy, Department of Prosthodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, 162, Poonamallee High Road, Chennai – 600 077, Tamil Nadu, India

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    Author:

    P. Kalyani, Dhanraj Ganapathy*, R. M. Visalakshi

    Title:Effectiveness of cyclooxygenase-2 inhibitors in the management of post-extraction pain
    Journal:Drug Invention Today
    Vol(issue):12 (May)
    Year:2019
    Page No: (1063-1066)
  • Experimental Methods Keywords

    Methodology: Conventional nonsteroidal anti-inflammatory drugs, Extraction, Pain, Selective cyclooxygenase-2 inhibitors
    Research Materials:Dental pain

Keywords

Conventional nonsteroidal anti-inflammatory drugs Extraction Pain Selective cyclooxygenase-2 inhibitors

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