Journal: Inter. J. of Chemical and Analytical Science

Article Id: JPRS-AC-0000356
Title: Spectrophotometric Estimation of Gemifloxacin in bulk and Pharmaceutical dosage form by UV Spectrophotometry
Category: Analytical Chemistry
Section: Research Article
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    The present study describes a simple, accurate, precise and cost effective UV-VIS Spectrophotometric method for the estimation of Gemifloxacin, a fluroquinolone derivative, in bulk and pharmaceutical dosage form. The solvent used was double distilled water and the lmax or the absorption maxima of the drug was found to be 269nm. A linear response was observed in the range of 2-10μg/ml with a regression coefficient of 0.999. The method was then validated for different parameters as per the ICH [2] (International Conference for Harmonization) guidelines. This method can be used for the determination of Gemifloxacin in quality control of formulation without interference of the excipients.

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    Author(s) Name:

    Suddhasattya Dey¹, Y.Vikram Reddy¹, Bala Krishna1, Sudhhir Kumar Sahoo2, P.N. Murthy2, Dhiraj Kumar2, Juneid Alam2 and Manik Ghosh3

    Affiliation(s) Name:

    1 Guru Nanak Institute of Pharmacy, Ibrahimpatnam,Hyderabad-501506, Dist-Ranga Reddy, Andhra Pradesh, In reply to India.
    ² Royal College of Pharmacy and Health Sciences,Berhampur-760002, Dist.-Gangam, Orissa, India.3Birla Institute of Technology, Mesra-835215, Ranchi, Jharkhand, India

    *Corresponding author.
    Suddhasattya Dey
    Guru Nanak Institute of Pharmacy, Ibrahimpatnam,Hyderabad-501506,
    Dist-Ranga Reddy, Andhra Pradesh, India.

    Received on: 20-02-2010; Revised on: 18-04-2010; Accepted on:23-05-2010

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    Author:

    Suddhasattya Dey¹, Y.Vikram Reddy¹, Bala Krishna1, Sudhhir Kumar Sahoo2, P.N. Murthy2, Dhiraj Kumar2, Juneid Alam2 and Manik Ghosh3

    Title:Spectrophotometric Estimation of Gemifloxacin in bulk and Pharmaceutical dosage form by UV Spectrophotometry
    Journal:Inter. J. of Chemical and Analytical Science
    Vol(issue):1 (June)
    Year:2010
    Page No: (130-134)
  • Experimental Methods Keywords

    Methodology:UV-VIS spectroscopy
    Research Materials:Gemifloxacin

Keywords

Gemifloxacin λmax ICH UV-VIS spectroscopy Fluroquinolones.

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