Journal: Drug Invention Today

Article Id: JPRS-P col-00003560
Title: Effectiveness of tranexamic acid and hemocoagulase for bleeding management in dental extraction patients – A pilot study
Category: Pharmacology
Section: Research Article
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    Aim: This study aims to compare the effectiveness of tranexamic acid and hemocoagulase (Botroclot) bleeding management in dental extraction patients. Background: Tranexamic acid is an antifibrinolytic agent that blocks lysine-binding sites on plasminogen, thereby reducing the local degradation of fibrin by plasmin. It works to stabilize and to inhibit the degradation of existing clots, and it is widely used to limit bleeding in clinical practice. Hemocoagulase reduces the bleeding time and promotes wound healing by promoting the growth of capillaries in wound space. Methodology: A total of 10 periodontally compromised patients requiring bilateral extraction were selected. Post-extraction, bleeding cessation was estimated by placing tranexamic acid soaked gauze on the extraction socket. After a week, the patients were recalled for extraction on contralateral side, bleeding cessation was estimated by placing hemocoagulase soaked gauze on the extraction socket. The bleeding time was noted and bleeding scores were estimated in both hemostatic agent patients. Results: Bleeding from extraction sockets was successfully ceased by compression of socket with the topical hemostatic agents soaked in gauze. There was no significant difference between tranexamic acid and hemocoagulase (P = 0.7) observed in bleeding management post-dental extraction. Conclusion: There is no significant difference between tranexamic acid and hemocoagulase in bleeding management; hence, both hemostatic agents are equally effective in the management of bleeding post-extraction.

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    Author(s) Name:

    Kiruthika Patturaja1 , Dhanraj Ganapathy2* , R. M. Visalakshi 2

    Affiliation(s) Name:

    1 Department of Prosthodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Prosthodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. Dhanraj Ganapathy, Department of Prosthodontics, Saveetha Dental College and hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai – 600 077, Tamil Nadu, India.

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    Author:

    Kiruthika Patturaja1 , Dhanraj Ganapathy2* , R. M. Visalakshi 2

    Title:Effectiveness of tranexamic acid and hemocoagulase for bleeding management in dental extraction patients – A pilot study
    Journal:Drug Invention Today
    Vol(issue):12 (May)
    Year:2019
    Page No: (1067-1070)
  • Experimental Methods Keywords

    Methodology:Bleeding,Hemostasis
    Research Materials:tranexamic acid and hemocoagulase

Keywords

Bleeding Hemocoagulase Hemostasis Tranexamic acid

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