Journal: Drug Invention Today

Article Id: JPRS-P col-00003563
Title: Flavonoids used in the treatment of malignancy – A review
Category: Pharmacology
Section: Research Article
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    The aim of the review is to give an insight into the role of flavonoids in the treatment of malignancy. Flavonoids (or bioflavonoids) are a class of plant and fungus secondary metabolites. Chemically, flavonoids have the general structure of a 15-carbon skeleton, which consists of two phenyl rings (A and B) and heterocyclic ring (C). This carbon structure can be abbreviated C6-C3-C6. Other promising anticancer agents include flavopiridol, roscovitine, combretastatin A-4, betulinic acid, and silvestrol. From this list, one can well imagine the predominance of polyphenols, flavonoids and their synthetic analogs in the treatment of ovarian, breast, cervical, pancreatic, and prostate cancer. The role of flavonoids also includes the inhibition of activation of pro-carcinogens, inhibition of proliferation of cancer cells, selective death of cancer cells by apoptosis, inhibition of metastasis and angiogenesis, activation of the immune response against cancer cells, and modulation of the inflammatory cascade.

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    Author(s) Name:

    V. Lavanya1 , Dhanraj Ganapathy2 *, R. M. Visalakshi 2

    Affiliation(s) Name:

    1 Department of Prosthodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Prosthodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. Dhanraj Ganapathy, Department of Prosthodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, 162, Poonamallee High Road, Chennai – 600 077, Tamil Nadu, India.

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    Author:

    V. Lavanya1 , Dhanraj Ganapathy2 *, R. M. Visalakshi 2

    Title:Flavonoids used in the treatment of malignancy – A review
    Journal:Drug Invention Today
    Vol(issue):12 (May)
    Year:2019
    Page No: (1082-1085)
  • Experimental Methods Keywords

    Methodology:Cancer,Malignancy, Proliferation and Treatment
    Research Materials:Flavonoids

Keywords

Cancer Flavonoids Malignancy Proliferation and Treatment

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