Journal: Drug Invention Today

Article Id: JPRS-P col-00003574
Title: Diallyl disulfide improves the liver antioxidant potential in diabetes-mediated oxidative damage in rats
Category: Pharmaceutics
Section: Research Article
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    Background: Oxidative stress is a pathological state, wherein oxidative forces surpass the antioxidant systems due to the loss of balance between them, leads to several diseased conditions including diabetes mellitus (DM), atherosclerosis, hypertension, ischemic diseases, and malignancies. Experimental and clinical studies evidenced that the chronic hyperglycemia in diabetes is associated with oxidative stress-mediated tissue damage. Among the various tissues, liver tissue is more susceptible to oxidative stress due to relatively less intrinsic antioxidant defense system. Diallyl disulfide (DADS) is an organosulfur compound which possesses diverse biological properties such as anti-inflammatory and antioxidant. Aim: The present study was aimed to investigate the effect of DADS on hyperglycemia-mediated oxidative damage in liver tissues of alloxan-induced diabetic rats. Methodology: Diabetic rats were treated with DADS (100 mg/kg b. w.) orally for 30 days. Results: The results indicates that DADS feeding significantly improved hepatic glutathione peroxidase, superoxide dismutase, and catalase enzyme activities where as a fall in lipid peroxide levels, which is further evidenced by histological studies. Conclusion: The therapeutic potential of DADS on the extent of oxidative stress was assessed by determining the levels of lipid peroxide, glutathione peroxidase, superoxide dismutase, and catalase enzyme activities in liver tissues. Liver histological observation also clearly evidenced the protective role of DADS against hyperglycemia-mediated oxidative damage which, in turn, attributed to the antioxidant potential of the DADS.

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    Author(s) Name:

    Prashanthkumar Goudappala1,2 , Ethirajan Sukumar1 , R T. Kashinath3 *

    Affiliation(s) Name:

    1 Department of Research and Development, Saveetha Institute of Medical And Technical Sciences (SIMATS), Thandalam, Chennai, India,

    2 Department of Biochemistry, Subbaiah Institute of Medical Sciences, Shivamogga, Karnataka, India,

    3 Department of Research and Development, Subbaiah Institute of Medical Sciences, Shivamogga, Karnataka, India

    *Corresponding author: Dr. R. T. Kashinath, Department of Research and Development, Subbaiah Institute of Medical Sciences, NH-13, Shivamogga - 577 222, Karnataka, India

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    Author:

    Prashanthkumar Goudappala1,2 , Ethirajan Sukumar1 , R T. Kashinath3 *

    Title:Diallyl disulfide improves the liver antioxidant potential in diabetes-mediated oxidative damage in rats
    Journal:Drug Invention Today
    Vol(issue):11 (June )
    Year:2019
    Page No: (1271-1276)
  • Experimental Methods Keywords

    Methodology:Hyperglycemia,Antioxidant potential,Oxidative damage
    Research Materials:Diallyl disulfide

Keywords

Antioxidant potential Diallyl disulfide Hyperglycemia Liver Oxidative damage

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