Journal: Drug Invention Today

Article Id: JPRS-P col-00003577
Title: Antistaphylococcal spectrum activity of Cinnamomum burmannii stem bark extract
Category: Pharmaceutics
Section: Research Article
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    Aim: This research study was performed to determine the antistaphylococcal spectrum activity of Cinnamomum burmanii stem bark extracts from Indonesia on Staphylococcus species as follows: Staphylococcus epidermidis ATCC 13228, Staphylococcus xylosus ATCC 3342, Staphylococcus aureus ATCC 11784, Staphylococcus warneri ATCC 3340, and Staphylococcus haemolyticus ATCC 3741. Materials and Methods: The antistaphylococcal spectrum of the extract was assayed on Staphylococcus strains using the agar diffusion method. The minimum inhibitory concentration value (MIC) was done using macrodilution method and followed by subculturing the overnight MIC result onto the surface of agar media to determine the minimum bactericidal concentration (MBC) value. In addition, the antistaphylococcal potency of the extract was compared to neomycin sulfate. Results and Discussion: Flavonoids, tannins, polyphenols, saponins, monoterpenoids, sesquiterpenoids, and quinones were detected in C. burmanii stem bark extracts. Those metabolites supported the significant result of antistaphylococcus spectrum of the extract against Staphylococcus strains. The strongest activity of the extract was achieved against S. epidermidis and the weakest was on S. xylosus. The MIC and MBC values were various in ranged: S. epidermidis ATCC 13228 (0.25–0.50% w/v), S. xylosus ATCC 3342 (3.00–3.50% w/v), S. aureus ATCC 11784 (0.75–1.00% w/v), S. warneri ATCC 3340 (0.75–1.00% w/v), and S. haemolyticus ATCC 3741 (0.50–2.00% w/v). The comparative analysis of the extracts indicated that neomycin sulfate demonstrated greater antibacterial activity against S. epidermidis ATCC 13228 than the extract (1:2.047.10−4 ). Conclusion: The ethanolic extract of C. burmanii stem bark exhibited a wide spectrum of antistaphylococcal activities.

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    Author(s) Name:

    Sri Agung Fitri Kusuma1 *, Dewi Rusmiati 1 , Adjeng Larasaty Asyanti 1 , Yaya Rukayadi 2

    Affiliation(s) Name:

    1 Department of Biology Pharmacy, Faculty of Pharmacy, Padjadjaran University, Sumedang, West Java 45363, Indonesia,

    2 Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, Serdang, Malaysia

    *Corresponding author: Sri Agung Fitri Kusuma, Department of Biology Pharmacy, Faculty of Pharmacy, Padjadjaran University, Sumedang, West Java 45363, Indonesia.

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    Author:

    Sri Agung Fitri Kusuma1 *, Dewi Rusmiati 1 , Adjeng Larasaty Asyanti 1 , Yaya Rukayadi 2

    Title:Antistaphylococcal spectrum activity of Cinnamomum burmannii stem bark extract
    Journal:Drug Invention Today
    Vol(issue):11 (June )
    Year:2019
    Page No: (1287-1291)
  • Experimental Methods Keywords

    Methodology:Antistaphylococcal spectrum activity
    Research Materials:Cinnamomum burmanii

Keywords

Antistaphylococcus Cinnamomum burmanii Extract Indonesia Stem bark

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