Journal: Inter. J. of Chemical and Analytical Science

Article Id: JPRS-DD-0000358
Title: Development and characterization of niosomal drug delivery of α-tocopherol
Category: Drug Delivery
Section: Research Article
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    The present study is an aim to overall improvement in the efficacy, reduced toxicity and enhancement of therapeutic index of niosome carrying α-tocopherol.Niosome were prepared by reverse phase evaporation method using span and tween (20 and/or 60).The preparations were characterize with respect to size reduction, entrapment efficiency, in-vitro drug release profile and stability under specific conditions. The diameter of niosomes ranges from 1-5μm with discrete and round in shape.The percent entrapment efficiency of the vesicles was found to be 67.84 %, 61.17%, 75.13% and 79.63% for F1, F2, F3 and F4 respectively. Highly cumulative release was observed with 81.78 % for span 20, 75.92% for span 60, 96.01% for tween 20 and 92.35 % for tween 60 respectively. Stability studies proved that optimum storage condition for niosomes was found to be 40C.

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    Author(s) Name:

    Anita R. Desai*, Raghuveer.I1, H. R. Chitme2 and Ramesh Chandra3

    Affiliation(s) Name:

    *Department of Pharmaceutics, H. S. K. College of Pharmacy, B.V.V.S Campus, Bagalkot-587101, Karnataka, India
    1Bundelkhand University, Jhansi-284128, U.P., India
    2Department of Pharmacology, Oman Medical College, Azaiba-620, Muscat, Sultanate of Oman
    3University of Delhi, Delhi-11007, India.


    Received on: 26-03-2010; Revised on: 19-05-2010; Accepted on:14-06-2010

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    Author:

    Anita R. Desai*, Raghuveer.I1, H. R. Chitme2 and Ramesh Chandra3

    Title:Development and characterization of niosomal drug delivery of α-tocopherol
    Journal:Inter. J. of Chemical and Analytical Science
    Vol(issue):1 (July)
    Year:2010
    Page No: (146-148)
  • Experimental Methods Keywords

    Methodology:Niosomes
    Research Materials:α-tocopherol

Keywords

Niosomes α-tocopherol Span and Tween (20 and/or 60).

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