Journal: Inter. J. of Chemical and Analytical Science

Article Id: JPRS-AC-0000360
Title: A Validated Spectrophotometric methods for the determination of Ziprasidone as Hydrochloride in Bulk and pharmaceutical formulations
Category: Analytical Chemistry
Section: Research Article
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    Three simple, sensitive, selective and accurate Spectrophotometric methods (M1 to M 3) for the determination of Ziprasidone Hydrochloride (ZPD.HCl) in bulk drug and pharmaceutical formulations (tablets) have been described. Three individual methods are based on the charge transfer complex formation (M1), Inner salt formation (M2) and Precipitation/complex formation reaction (M3) of drug with different reagents to form colored chromogens exhibiting lmax 540 (M1), 580 (M2) and 470 (M3) nm respectively. The results of analysis for the three methods have been validated statistically and by recovery studies. The results are compared with those obtained using UV Spectrophotometric method in isopropyl alcohol at 229 nm.

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    Author(s) Name:

    Medikondu Kishorea*, Y.Hanumantharaob

    Affiliation(s) Name:

    a*Department of chemistry, Nalanda Degree and Post graduation college, Krishna (Dist). Andhra Pradesh, India
    bDepartment of chemistry, Andhra Loyola College (Autonomous), Vijayawada, Krishna (Dist). AndhraPradesh, India

    *Corresponding author.
    Dr Medikondu Kishore, Associate Professor and Head Department of
    Chemistry, Nalanda Degree and PG College, Labbipet, Vijayawada, Krishna
    (District), Andhra Pradesh, India.


    Received on: 26-03-2010; Revised on: 12-05-2010; Accepted on:24-06-2010

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    Author:

    Medikondu Kishorea*, Y.Hanumantharaob

    Title:A Validated Spectrophotometric methods for the determination of Ziprasidone as Hydrochloride in Bulk and pharmaceutical formulations
    Journal:Inter. J. of Chemical and Analytical Science
    Vol(issue):1 (July)
    Year:2010
    Page No: (151-153)
  • Experimental Methods Keywords

    Methodology:Spectrophotometric methods, Statistical analysis, drug recovery studies
    Research Materials:Ziprasidone Hydrochloride

Keywords

Ziprasidone Hydrochloride Spectrophotometric methods Statistical analysis drug recovery studies

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