Journal: Drug Invention Today

Article Id: JPRS-P col-00003608
Title: Salivary proteins and its effects on dental caries – A review
Category: Pharmaceutics
Section: Review Article
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    The aim of this review is to determine the relationship between salivary proteins and dental caries. Caries is a common disease process that afflicts a large proportion of the child population worldwide. Extensive research in the past indicates that it is the result of bacterial infection, also influenced by host and dietary factors. The current caries research seeks to identify risk factors as well as natural oral defenses that may protect against or prevent caries development. Saliva, in spite of being the strongest defense system, still has a wide array of properties and proteins whose role is yet not clearly known. Saliva is essential for a lifelong conservation of the dentition. Various functions of saliva are implicated in the maintenance of oral health and the protection of our teeth: (1) The tooth surface is continuously protected against wear by a film of salivary mucins and proline-rich glycoprotein. (2) The early pellicle proteins, proline-rich proteins, and statherin promote remineralization of the enamel by attracting calcium ions. (3) Demineralization is retarded by the pellicle proteins, in concert with calcium and phosphate ions in saliva and in the plaque fluid. (4) Several salivary (glyco) proteins prevent the adherence of oral microorganisms to the enamel pellicle and inhibit their growth. (5) The salivary bicarbonate/carbonate buffer system is responsible for rapid neutralization of acids. This review summarizes the relationship between the dental caries and tooth- protective salivary proteins with their potential as functional biomarkers for caries risk assessment.

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  • About the authors and Affiliations

    Author(s) Name:

    Harish Devarajan1 , Sujatha Somasundaram2 *

    Affiliation(s) Name:

    1 Department of Pedodontics and Preventive Dentistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Pedodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. Sujatha Somasundaram, Department of Pedodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, Tamil Nadu, India.

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    Author:

    Harish Devarajan1 , Sujatha Somasundaram2 *

    Title:Salivary proteins and its effects on dental caries – A review
    Journal:Drug Invention Today
    Vol(issue):11 (June )
    Year:2019
    Page No: (1406-1411)
  • Experimental Methods Keywords

    Methodology:Dental caries, Salivary functions, Salivary microorganism, effects
    Research Materials:Salivary protein

Keywords

Dental caries Salivary functions Salivary microorganism Salivary proteins

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