Journal: Inter. J. of Chemical and Analytical Science

Article Id: JPRS-AC-0000361
Title: New Aurum Coupling Reaction for Visible Spectrophotometric Determination of Tolterodine Tartrate in Pharmaceutical Preparations
Category: Analytical Chemistry
Section: Research Article
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    Simple, rapid and sensitive spectrophotometric procedures were developed for the analysis of Tolterodine Tartrate (TT) in pure form as well as in pharmaceutical formulations. The methods are based on the reaction of TT with gold (III) chloride in the pH range 1.0 – 5.0 forming violet colored complex solution, showing absorption maxima at 540 nm. The linear plot indicates that Beer’s law is obeyed in the range of 10 – 90 μg/ml of tolterodine tartrate. The molar absorptivity and Sandell’s sensitivity are 5.43 x 103 l mol-1 cm-1 and 0.0876 μg/cm2 respectively. The standard deviation of the method for ten determinations of 20 μg/ml of tolterodine tartrate is 9.49 x 10-4. The correlation coefficient (?) of the experimental data of the calibration plot is 0.9989. The effective range of concentration for accurate determination of tolterodine tartrate as ascertained from Ringbom’s plot and it is 20 – 90 μg/ml.

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    Author(s) Name:

    B. Mohammed Ishaq*1, Dr. K. Vanitha Prakash1, B. Manjula2, C. Hari Kumar3, G. Usha Rani4

    Affiliation(s) Name:

    1Dept. of Pharmaceutical Analysis, SSJ College of Pharmacy, Gandipet, Hyderabad, INDIA.
    2Avanthi Institute of Pharmacy, Hyderabad, INDIA.
    3Deccan Schooll of Pharmacy, Hyderabad, INDIA.
    4CMR College of Pharmacy, Hyderabad, INDIA.

    *Corresponding author.
    B. Mohammed Ishaq,
    Flat no – 208, Sheshadri block,
    7 hills apartments, Nizampet road,
    Hyderabad – 500 075, A.P,India


    Received on: 23-04-2010; Revised on: 09-05-2010; Accepted on:12-06-2010

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    Author:

    B. Mohammed Ishaq*1, Dr. K. Vanitha Prakash1, B. Manjula2, C. Hari Kumar3, G. Usha Rani4

    Title:New Aurum Coupling Reaction for Visible Spectrophotometric Determination of Tolterodine Tartrate in Pharmaceutical Preparations
    Journal:Inter. J. of Chemical and Analytical Science
    Vol(issue):1 (July)
    Year:2010
    Page No: (165-167)
  • Experimental Methods Keywords

    Methodology:Spectrophotometric Determination
    Research Materials:Tolterodine Tartrate

Keywords

Tolterodine Tartrate spectrophotometric Beer’s law Ringbom’s plot.

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