Journal: Drug Invention Today

Article Id: JPRS-P col-00003616
Title: Mast cell disorders in periodontal disease
Category: Pharmaceutics
Section: Review Article
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  • Abstract

    The aim of the review is to give an insight into the role of mast cells (MCs) and its disorders in periodontal health and disease. MCs are mobile, bone marrow-derived, granule-containing immune cells that are found in all connective tissue and mucosal environments and the peripheral and central nervous systems. MCs are able to phagocytose, process and present antigens as effectively as macrophages. MC disorders are conditions in which MCs are either increased in number, hyper-reactive, or both. These conditions range in severity from relatively benign disorders that do not impact life span to malignant clonal diseases that progress rapidly. Recently, MCs were found in high numbers in chronically inflamed gingival tissue taken from patients with chronic marginal periodontitis. This topic will review the classification of MC disorders, provide a brief clinical description of each disorder and highlights the role of MCs in periodontal health and disease.

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  • About the authors and Affiliations

    Author(s) Name:

    G. Cathrine1 , Priya Lochana Gajendran2 *

    Affiliation(s) Name:

    1 Department of Periodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India,

    2 Department of Periodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India

    *Corresponding author: Dr Priya Lochana Gajendran, Department of Periodontics, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, 162, Poonamallee High Road, Chennai - 600 077, Tamil Nadu, India.

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    Author:

    G. Cathrine1 , Priya Lochana Gajendran2 *

    Title:Mast cell disorders in periodontal disease
    Journal:Drug Invention Today
    Vol(issue):11 (June )
    Year:2019
    Page No: (1435-1440)
  • Experimental Methods Keywords

    Methodology:Mast cell disorders, Inflammation, Innate immunity
    Research Materials:Connective tissue

Keywords

Connective tissue Inflammation Innate immunity Mast cell Oral mucosa; periodontitis

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