Journal: Drug Invention Today

Article Id: JPRS-D(DD)-00003619
Title: Mucoadhesive oral in situ gel of itraconazole using pH-sensitive polymers: Preparation, and in vitro characterization, release and rheology study
Category: Drug (Discovery/Development)
Section: Research Article
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    Objective: The study was to design a mucoadhesive pH-triggered in situ gel of itraconazole, to prolong the residence time on oral mucosa, and to reduce the frequency of application and amount of drug administrated. Materials and Methods: Six formulations containing itraconazole 1% were prepared using different concentrations (0.5 and 0.7% w/w) of carbopol 934 (CB) and in combination with different viscosity-enhancing agents such as hydroxypropyl methylcellulose (HPMC) K4M (1 and 1.5%), xyloglucan (0.5%), and hyaluronic acid (1%), to formulate a pH-triggered system that undergoes sol-to-gel transition on change in pH to the physiological pH. The formulations were evaluated for physical appearance, PH, gelation capacity, rheological properties, spreadability, mucoadhesive force, and in vitro release of drug. Results: Formula F4 (0.7% CB, 1.5% HPMC K4M) showed acceptable pH and appearance, acceptable gelling capacity, and shear thinning rheological property, good mucoadhesive force, and provided 80% release over a 6-h period. Conclusion: The developed itraconazole mucoadhesive oral in situ gel was non-irritant, retarded the release for 6 h, and it is good alternative to conventional oral gel.

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    Author(s) Name:

    Roaa A. Nief*, Manar Adnan Tamer, Shaimaa Nazar Abd Alhammid

    Affiliation(s) Name:

    Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad, Iraq

    *Corresponding author: Roaa A. Nief, Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad, Iraq.

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    Author:

    Roaa A. Nief*, Manar Adnan Tamer, Shaimaa Nazar Abd Alhammid

    Title:Mucoadhesive oral in situ gel of itraconazole using pH-sensitive polymers: Preparation, and in vitro characterization, release and rheology study
    Journal:Drug Invention Today
    Vol(issue):11 (June )
    Year:2019
    Page No: (1450-1455)
  • Experimental Methods Keywords

    Methodology:Mucoadhesive in situ gel, Preparation, and in vitro characterization, release , rheology study
    Research Materials: Itraconazole

Keywords

Carbopol 934 Hydroxypropylmethylcellulose Itraconazole Mucoadhesive in situ gel

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