Journal: JPR:BioMedRx:An International Journal

Article Id: JPRS-Pha-0000362
Title: Evaluation of anticancer activity of Andaman freeze dried powdered Morinda citrifolia L. fruit against Ehrlich Ascites Carcinoma (EAC) cell induced liquid and solid tumor in Swiss Albino mice.
Category: Pharmacology
  • Abstract
  • Audio Abstract
  • Authors
  • Pdf File
  • Citation
  • My Reference
  • Methodology
  • Abstract

    Objective: The objective of the study was to establish the antitumor effect of powdered freeze dried Noni against Swiss albino mice bearing liquid tumor in peritoneal cavity and solid tumor in hind limb induced by Ehrlich ascites carcinoma (EAC) cell lines. Methods: For liquid tumor study Noni at doses 250 and 500 mg/kg body weight were administered to mice carrying EAC cell line up to 14 consecutive days. Half of the mice were sacrificed, for the assessment of antitumor activity by evaluating tumor parameters and hematological parameters and rest half were left for the survival studies by mean survival time (MST) and percent increase in life span (%ILS). For solid tumor study, tumor was induced by implanting EAC cell subcutaneously in the hind limb of mice. Same doses were used and mice were sacrificed after 21 days for evaluating tumor weight and tumor volume. Histopathological studies of tumor, liver and kidney were performed. Results: In liquid tumor, it was found that Noni significantly (p<0.01) decreases tumor volume, tumor weight, viable tumor cell count and increases the life span of mice bearing EAC cell lines. Hematological parameters gained their normal values. In solid tumor, Noni at both doses decreased tumor weight and Noni 500mg/kg decreased tumor volume significantly (p<0.05). Histopathological findings revealed that Noni showed less proliferation with some necrosis and apoptosis along with hepatoprotective and renoprotective action on liver and kidney. Conclusion: It was revealed from the experimental results that the powdered freeze dried Noni has potent antitumor activity.

  • Abstract Audio

    Click Here

  • About the authors and Affiliations

    Author(s) Name:

    Hariom Singh, Saswata Banerjee, Saumen Karan, Tapan Kumar Chatterjee*

    Affiliation(s) Name:

    Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.

    *Corresponding author.
    Dr. Tapan Kumar Chatterjee,
    Assosciate Professor,
    Division of Pharmacology,
    Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032.


    Received on:16-01-2013; Revised on:19-02-2013; Accepted on:24-03-2013

  • View Article File in pdf format.

    Article File
  • View Article Citation Here.

    0 View More
  • How to Cite my Article.

    Author:

    Hariom Singh, Saswata Banerjee, Saumen Karan, Tapan Kumar Chatterjee*

    Title:Evaluation of anticancer activity of Andaman freeze dried powdered Morinda citrifolia L. fruit against Ehrlich Ascites Carcinoma (EAC) cell induced liquid and solid tumor in Swiss Albino mice.
    Journal:JPR:BioMedRx:An International Journal
    Vol(issue):1(6)
    Year:2013
    Page No: (567-573)
  • Experimental Methods Keywords

    Methodology:Evaluation of anticancer activity
    Research Materials:Morinda citrifolia L

Keywords

Freeze dried Noni EAC cell line anticancer activity 5-Flurouracil Paclitaxel

Our Services

Most Downloaded List