Journal: Drug Invention Today

Article Id: JPRS-P col-00003652
Title: Lupeol regulates glucose transporter-4 and AS160 in adipose tissue of high-fat diet-fed diabetic rats
Category: Pharmaceutics
Section: Research Article
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    Background: Lupeol, a natural herbal drug, is abundant in edible vegetables, fruits, and also in medicinal plants. There are reports showing that lupeol can reduce hyperglycemia and hyperinsulinemia in experimental mice model. Objective: The objective of this study was to identify the effect of lupeol on glucose transporter (GLUT)-4 and AS160 protein expression in adipose tissue of high-fat diet and sucrose-induced Type-2 diabetic (T2D) rats. Materials and Methods: Lupeol was administered orally to T2D rats (25 mg/kg body weight) for a period of 30 days. After the treatment period, animals were anesthetized and liver from control and experimental animals was dissected out and used for the protein expression of GLUT-4 and AS160 in adipose tissue. Results: Lupeol treatment increased GLUT-4 protein level in the T2D animals. Conclusion: It is concluded from the present findings that lupeol has antihyperglycemic activity through the regulation of insulin signaling molecules (GLUT-4 and AS160). Hence, lupeol can be used as one of the therapeutic agents for the management of T2D.

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    Author(s) Name:

    S. Kamala Devi 1 , V. Vishnu  Priya1 , R. Ponnulakshmi 2 , R. Gayathri 1 , B. Shyamaladevi 1 , K. Madhan1 , Adithya R. Pillai 2 , J. Selvaraj1 *

    Affiliation(s) Name:

    1 Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University,

    2 Department of Central Research Laboratory, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. J. Selvaraj, Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, Tamil Nadu, India.

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    Author:

    S. Kamala Devi 1 , V. Vishnu  Priya1 , R. Ponnulakshmi 2 , R. Gayathri 1 , B. Shyamaladevi 1 , K. Madhan1 , Adithya R. Pillai 2 , J. Selvaraj1 *

    Title:Lupeol regulates glucose transporter-4 and AS160 in adipose tissue of high-fat diet-fed diabetic rats
    Journal:Drug Invention Today
    Vol(issue):12 (June)
    Year:2019
    Page No: (1188-1190)
  • Experimental Methods Keywords

    Methodology: AS160, Glucose transporter-4, High-fat diet rat, Type-2 diabetes
    Research Materials:Lupeol

Keywords

AS160 Glucose transporter-4 High-fat diet rat Lupeol Type-2 diabetes

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