Journal: Drug Invention Today

Article Id: JPRS-P col-00003675
Title: Effect of beta-sitosterol on glucose oxidation in liver of type-2 diabetic rats
Category: Pharmaceutics
Section: Research Article
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    Background: Beta-sitosterol which is one of the most common sterols found in plants and some vegetable oils. However, the effect of β-sitosterol on glucose uptake and oxidation in liver is not known. Objectives: The study aimed to identify the effects of beta-sitosterol on 14 C-glucose oxidation and 14 C-2-deoxyglucose uptake in hepatocytes in high-fat diet and sucrose-induced type-2 diabetic rats. Materials and Methods: β-sitosterol was administered orally to type-2 diabetic rats (20 mg/kg body weight) for a period of 30 days. After the treatment period, animals were anesthetized and liver from control and experimental animals was dissected out and the glucose uptake and oxidation in the liver were analyzed using scintillation counter (β-counter). Results: In type-2 diabetic animals, the 14 C-glucose oxidation and 14 C-2-deoxyglucose were found to be decreased due to high-fat diet-induced insulin resistance. The β-sitosterol treatment (20 mg/kg b.wt) significantly raised the glucose uptake and oxidation in the liver of type-2 diabetic rats as a result of increased insulin sensitivity mediated increase in insulin-signaling molecules. Conclusion: Our present finding indicates that the antidiabetic activity of β-sitosterol regulates glucose homeostasis through the regulation of glucose uptake and oxidation as a result of increase in the insulin sensitivity in liver of type-2 diabetic rats.

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    Author(s) Name:

    M. Ashritha1 , V. Vishnupriya1 , R. Ponnulakshmi 2 , R. Gayathri 1 , K. Madhan1 , B. Shyamaladevi 1 , J. Selvaraj 1 *

    Affiliation(s) Name:

    1 Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Central Research Laboratory, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. J. Selvaraj, Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, 162, Poonamallee High Road, Chennai - 600 077, Tamil Nadu, India.

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    Author:

    M. Ashritha1 , V. Vishnupriya1 , R. Ponnulakshmi 2 , R. Gayathri 1 , K. Madhan1 , B. Shyamaladevi 1 , J. Selvaraj 1 *

    Title:Effect of beta-sitosterol on glucose oxidation in liver of type-2 diabetic rats
    Journal:Drug Invention Today
    Vol(issue):12 (June)
    Year:2019
    Page No: (1272-1274)
  • Experimental Methods Keywords

    Methodology:type-2 diabetic,glucose oxidation, 14 C-2-deoxyglucose uptake, 14 C-glucose oxidation
    Research Materials:beta-sitosterol

Keywords

14 C-2-deoxyglucose uptake 14 C-glucose oxidation Beta-sitosterol Liver

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