Journal: Drug Invention Today

Article Id: JPRS-P col-00003687
Title: Evaluation of antidiabetic effect of Nerium oleander flowers - An in vitro study
Category: Pharmaceutics
Section: Research Article
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    Aim: The aim of the study was to evaluate the antidiabetic effect of Nerium oleander flower. Introduction: N. oleander belonging to the family Apocynaceae is used for the treatment of diverse ailments such as cancer, asthma, and diabetes. Diabetes is a metabolic disorder which is the world’s fastest-growing chronic disorder. Materials and Methods: The methanolic extract of N. oleander flowers (NOME) was prepared. The in vitro antidiabetic effect of NOME was studied using α-amylase inhibition assay and glucose uptake assay. Results: The NOME treatment caused inhibition of α-amylase in a concentration-dependent manner. The α-amylase prevents the breakdown of polysaccharide to glucose. Also the treatment of NOME caused enhanced glucose uptake in rat L6 myogenic cells. Hence, these results revealed the effect of the extract in decreasing the blood glucose level. Conclusion: N. oleander flowers showed potent in vitro antidiabetic activity.

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    Author(s) Name:

    M. Magdalene1 , S. Kavitha2 *, V. Vishnu Priya2 , R. Gayathri 2

    Affiliation(s) Name:

    1 Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: S. Kavitha, Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, 160, Poonamallee High Road, Chennai–600 077, Tamil Nadu, India.

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    Author:

    M. Magdalene1 , S. Kavitha2 *, V. Vishnu Priya2 , R. Gayathri 2

    Title:Evaluation of antidiabetic effect of Nerium oleander flowers - An in vitro study
    Journal:Drug Invention Today
    Vol(issue):12 (June)
    Year:2019
    Page No: (1313-1315)
  • Experimental Methods Keywords

    Methodology:α-amylase, Antidiabetic effect, Diabetes
    Research Materials:Nerium oleander flowers

Keywords

α-amylase Antidiabetic effect Diabetes Nerium oleander flowers

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