Journal: JPR:BioMedRx:An International Journal

Article Id: JPRS-PDRS-0000369
Title: Evaluation of effect of methanolic extract of Stereospermum suaveolens in the asthmatic animal.
Category: Plant Drugs Related Study
Section: Research Article
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    Bronchial asthma is an inflammatory disorder of the airways characterized by various airway obstruction, airway inflammation and bronchial hyper responsiveness. Air-way hyper-responsiveness (AHR) involves infiltration of leukocytes into the airway wall, which is associated with increased expression of cytokines, enzymes, and adhesion molecules within the airway. The present investigation was undertaken to evaluate the mast cell stabilizing and bronchial hyperactivity of methanolic extract of Stereospermum suaveolens Linn(MESS), bark in experimental animals. For evaluation of antiasthmatic activity of MESS was studied on broncho alveolar lavage fluid (BALF) in the ova albumin sensitized mice, Lung histopathology in mice and mast cell stabilizing activity was studied using compound 48/80 as degranulatimg agent in rat model. Treatment with MESS showed Significant decreased in the total leukocyte and differential leukocyte count in the BALF and serum IgE antibody count of the ova albumin sensitized mice was observed by administration of MESS (250, 500 and 750mg/kg, p.o., for 7 days,). Methanolic extract show dose dependently protected the mast cell disruption induced by compound 48/80 in rat model. The extract significantly result (*p<0.05, **p<0.01) for both hyperactivity airway response model in mice and mast cell protection in rat model. Antioxidant assay show the significant result for this plant extract. Based on overall result, protection of mast cell, inflammatory mediator level, lung histopathology and lung wet weight to dry weight ratio and lung wet weight to body weight ratio, it was found that MESS has not only mast cell stabilizing activity but also decreases bronchial hyperactivity by decreasing the infiltration of inflammatory cells in the airway and inhibition of release of histamine like mediators from the mast cell by stabilizing it.

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    Author(s) Name:

    Sunil Bhalerao, Neeraj Vyawahare*, Tina Saldhana, Aakansha Dube, Sujata Taware.

    Affiliation(s) Name:

    AISSMS College of Pharmacy, near RTO, Kennedy Road, Pune-01.
    PADM. Dr. D Y Patil College of Pharmacy, Akurdi, Pune-35

     

    *Corresponding author.
    Dr. Neeraj S. Vyawahare
    Principal,
    Padm. Dr. D Y Patil College of Pharmacy,
    Akurdi, Pune,Maharastra,India.


    Received on:20-02-2013; Revised on:26-03-2013; Accepted on:28-04-2013

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    Author:

    Sunil Bhalerao, Neeraj Vyawahare*, Tina Saldhana, Aakansha Dube, Sujata Taware.

    Title:Evaluation of effect of methanolic extract of Stereospermum suaveolens in the asthmatic animal.
    Journal:JPR:BioMedRx:An International Journal
    Vol(issue):1 (June)
    Year:2013
    Page No: (599-607)
  • Experimental Methods Keywords

    Methodology:Estimation
    Research Materials:Stereospermum suaveolens

Keywords

Stereospermum suaveolens Respiratory disorder BAL fluid Asthma.

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