Journal: Journal of Pharmacy Research

Article Id: JPRS-PC-0000371
Title: Synthesis and Biological Activity of Novel Acyl Hydrazone Derivatives of 3-(4,5-diphenyl-1,3-oxazol-2-yl) propanoic acid as Anticancer, Analgesic and Anti-inflammatory Agents
Category: Pharmaceutical Chemistry
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    A series of acyl hydrazone derivatives of 3-(4,5-diphenyl-1,3-oxazol-2-yl) propanoic acid have been synthesized and screened for in vivo anti inflammatory, analgesic and in vitro anti cancer activities. The key intermediate N-acylhydrazine is prepared in good yield from NSAID oxaprozin, was coupled with a variety of aromatic aldehydes under conventional as well as microwave irradiation conditions. The microwave approach utilized solvent free condition, required short time and resulted in very good yields. The newly synthesized compounds have been characterized by IR, 1H NMR, 13C NMR and Mass analysis. The results of the biological activities showed that the compounds 5b, 5d and 5e exhibited significant in vivo analgesic and anti inflammatory activities than reference compound oxaprozin. Compounds 5a, 5b, 5e, 5g, 5h, 5i and 5j revealed promising in vitro cytotoxicity than reference compound Cisplatin.

    Cite this article as: Parsharamulu Rayam, Jaya Shree Anireddy, Naveen Polkam, Tejeswara Rao Allaka, Kalyani Chepuri and Mukharjee Nadendla,Synthesis and Biological Activity of Novel Acyl Hydrazone Derivatives of 3-(4,5-diphenyl-1,3-oxazol-2-yl) propanoic acid as Anticancer, Analgesic and Anti-inflammatory Agents, Journal of Pharmacy Research 2015,9(2),157-164

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    Author(s) Name:

    Parsharamulu Rayama, Jaya Shree Anireddya*, Naveen Polkama, Tejeswara Rao Allakaa, Kalyani Chepurib and Mukharjee Nadendlac

    Affiliation(s) Name:

    aCentre for Chemical Sciences and Technology, Institute of Science and Technology,
    Jawaharlal Nehru Technological University Hyderabad, Telangana-500 085. India.
    bCentre for Biotechnology, Institute of Science and Technology,
    Jawaharlal Nehru Technological University Hyderabad,Telangana-500 085. India.
    cGurram Balanarasaiah Institute of Pharmacy, Ghatkesar, Ranga Reddy, Hyderabad, Telangana-501 301. India.

    *Corresponding author.
    Jaya Shree Anireddy
    Centre for Chemical Sciences & Technology,
    Institute of Science & Technology,
    Jawaharlal Nehru Technological University Hyderabad,Kukatpally,
    Telangana-500085. India.


    Received on:21-12-2014; Revised on: 17-01-2015; Accepted on:25-02-2015

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    Author:

    Parsharamulu Rayama, Jaya Shree Anireddya*, Naveen Polkama, Tejeswara Rao Allakaa, Kalyani Chepurib and Mukharjee Nadendlac

    Title:Synthesis and Biological Activity of Novel Acyl Hydrazone Derivatives of 3-(4,5-diphenyl-1,3-oxazol-2-yl) propanoic acid as Anticancer, Analgesic and Anti-inflammatory Agents
    Journal:Journal of Pharmacy Research
    Vol(issue):9(2)
    Year:2015
    Page No: (157-164)
  • Experimental Methods Keywords

    Methodology:Synthesis and Biological Activity
    Research Materials:Novel Acyl Hydrazone Derivatives of 3-(4,5-diphenyl-1,3-oxazol-2-yl) propanoic acid

Keywords

Acyl hydrazones Analgesic activity Anti-inflammatory activity Cytotoxicity Oxaprozin.

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