Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000373
Title: Design, development and In vitro characterization of Felodipine Mucoadhesive buccal tablets
Category: Pharmaceutics
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    In recent years, there has been a growing interest in the use of delivery of therapeutic agent through various transmucosal routes to provide a therapeutic amount of drug to the proper site in body. The objective of this investigation was to develop and evaluate felodipine mucoadhesive buccal tablets using mucoadhesive polymers like HPMC K4M, SCMC and Carbopol 934P. The buccal tablets prepared by direct compression method. Pre and post compression parameters were found to be within specified limits. The tablets were evaluated for weight variation, drug content, hardness, friability, permeation studies and In vitro residence time. FTIR studies indicate that there is no interaction between drug and polymers. The result of permeation of drug indicates that the formulation- F5 showed maximum drug permeation up to 12 h and maximum in vitro residence time. The result indicates that felodipine mucoadhesive buccal tablets may be good choice to bypass hepatic first pass metabolism with an improvement in the bioavailability through buccal mucosa.

    Cite this article as: P. Dwarakanadha Reddy, R. Balanjineyulu, D.Swarnalatha, A.V Badarinath, C.Gopinath,Design, development and In vitro characterization of Felodipine Mucoadhesive buccal tablets,Journal of Pharmacy Research 2015,9(2),170-176.

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    Author(s) Name:

    P. Dwarakanadha Reddy*, R. Balanjineyulu, D.Swarnalatha, A.V Badarinath, C.Gopinath

    Affiliation(s) Name:

    Department of Pharmaceutics, Annamacharya College of Pharmacy, New Boyanapalli, Rajampet - 516 126, Andhra Pradesh, India.

    *Corresponding author.
    Dr. P. Dwarakanadha Reddy
    Department of Pharmaceutics,
    Annamacharya College of Pharmacy,
    New Boyanapalli, Rajampet - 516 126,
    Andhra Pradesh, India.


    Received on:21-12-2014; Revised on: 19-01-2015; Accepted on:26-02-2015

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    Author:

    P. Dwarakanadha Reddy*, R. Balanjineyulu, D.Swarnalatha, A.V Badarinath, C.Gopinath

    Title:Design, development and In vitro characterization of Felodipine Mucoadhesive buccal tablets
    Journal:Journal of Pharmacy Research
    Vol(issue):9(2)
    Year:2015
    Page No: (170-176)
  • Experimental Methods Keywords

    Methodology:Design, development and In vitro characterization
    Research Materials:Felodipine Mucoadhesive buccal tablets

Keywords

Felodipine HPMC K4M SCMC Carbopol-934P and Mucoadhesive buccal tablets

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