Journal: Drug Invention Today

Article Id: JPRS-P col-00003770
Title: Cytotoxic evaluation of onion oil on oral cancer cell
Category: Pharmacology
Section: Research Article
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    Aim: This research work was done to evaluate the anticancer potential of onion oil on oral cancer cell lines. Introduction: Onion (Allium cepa) herbaceous biennial plant belongs to the family Amaryllidaceae is grown for its edible bulb. Onion oil has flavoring properties that could enhance the quality of treated food. It has also been reported to have antioxidant, anti-browning, and antimicrobial properties Oral cancer is one of the most common malignancies in the world.The loss of regulation in cell division is the hallmark of all cancers. Materials and Methods: Onion oil was purchased commercially. The cytotoxicity of onion oil was studied by checking the cell viability using 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay (MTT assay) in KB cell lines. Results and Discussion: Onion oil decreased the cell viability in KB cell lines. The activity increases with increase in concentration of onion oil revealing its cytotoxicity in a concentration- dependent manner. Conclusion: This study established the potent in vitro cytotoxic effect of onion oil on oral cancer cell lines.

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    Author(s) Name:

    A. Aksha Sharen1 , S. Kavitha2 *, V. Vishnupriya2 , R. Gayathri 2

    Affiliation(s) Name:

    1 Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Biochemistry, Saveetha Dental College, Saveetha University, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: S. Kavitha, Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, 160, Poonamallee High Road, Chennai - 600 077, Tamil Nadu, India.

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    Author:

    A. Aksha Sharen1 , S. Kavitha2 *, V. Vishnupriya2 , R. Gayathri 2
    Title:Cytotoxic evaluation of onion oil on oral cancer cell
    Journal:Drug Invention Today
    Vol(issue):12 (July)
    Year:2019
    Page No: (1385-1387)

  • Experimental Methods Keywords

    Methodology:Cytotoxicity, KB cell lines, 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay
    Research Materials:onion oil

Keywords

Cytotoxicity KB cell lines 3-(4 5-dimethythiazol-2-yl)-2 5-diphenyl tetrazolium bromide assay Onion oil

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