Journal: Drug Invention Today

Article Id: JPRS-P col-00003771
Title: Antibacterial activity of Phaleria macrocarpa (Scheff.) Boerl fruit ethanolic extract against chloramphenicol-sensitive and resistant Staphylococcus aureus
Category: Pharmaceutics
Section: Research Article
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    Objective: This study was aimed to evaluate the antibacterial activity of Phaleria macrocarpa (Scheff.) Boerl fruit ethanolic extract against chloramphenicol-sensitive and resistant Staphylococcus aureus. Materials and Methods: The antibacterial activity of the extract was tested against those Staphylococcus strains using a well diffusion method. Then, the extract was serially diluted in broth medium and challenged by an inoculum of S. aureus strains to determine the lowest concentration of inhibition, which is defined as minimum inhibitory concentration (MIC) value. Results: The antibacterial activity exhibited that P. macrocarpa fruit extracts strongly inhibited the sensitive S. aureus but cannot inhibit the resistant strain. The antibacterial strength of P. macrocarpa fruit extracts was supported by the lowest MIC value data of the extract at the range of 0.391–0.781% w/v. Conclusion: The fruit extract of P. macrocarpa could be categorized as a strong candidate anti-staphylococcal from natural product.

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    Author(s) Name:

    Sri Agung Fitri Kusuma1 *, Retnowanti Khairunnisa2 , Dadan Suryasaputra2,3

    Affiliation(s) Name:

    1 Department of Biology Pharmacy, Faculty of Pharmacy, Padjadjaran University, Sumedang, West Java, Indonesia,

    2 Departement of Pharmacy, Faculty of Mathematics and Natural Sciences, Al-Ghifari University, Bandung, West Java, Indonesia,

    3 Faculty of Pharmacy, Jenderal Achmad Yani, Cimahi, West Java, Indonesia

    *Corresponding author: Sri Agung Fitri Kusuma, Department of Biology Pharmacy, Faculty of Pharmacy, Padjadjaran University, Sumedang, West Java 45363, Indonesia.

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    Author:

    Sri Agung Fitri Kusuma1 *, Retnowanti Khairunnisa2 , Dadan Suryasaputra2,3

    Title:Antibacterial activity of Phaleria macrocarpa (Scheff.) Boerl fruit ethanolic extract against chloramphenicol-sensitive and resistant Staphylococcus aureus
    Journal:Drug Invention Today
    Vol(issue):12 (July)
    Year:2019
    Page No: (1388-1391)
  • Experimental Methods Keywords

    Methodology:Antibacterial activity
    Research Materials:Phaleria macrocarpa (Scheff.) Boerl

Keywords

Chloramphenicol Extract Fruit Phaleria macrocarpa (Scheff.) Boerl Resistant Staphylococcus aureus

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