Journal: Drug Invention Today

Article Id: JPRS-P col-00003775
Title: Attenuation of diabetic nephropathy by a plant sterol lupeol: A biochemical analysis
Category: Pharmacology
Section: Research Article
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    Background: Lupeol is a triterpenoid and is found in vegetables such as white cabbage, pepper, cucumber, and tomato, in fruits such as olive, fig, mango, strawberry, and red grapes, and in medicinal plants such as American ginseng, shea butter plant, Tamarindus indica, Allanblackia monticola, Himatanthus sucuuba, Celastrus paniculatus, Zanthoxylum riedelianum, Leptadenia hastata, Crataeva nurvala, and Bombax ceiba (Saleem, 2009). Lupeol has been shown to exhibit various pharmacological activities under in vitro and in vivo conditions. Objectives: The study aimed to identify attenuation of diabetic nephropathy by a plant sterol lupeol the analysis of biochemical profile. Methodology: In the present study, experimental animals were divided into four groups each consisting of five animals. Group 1: Normal control, Group 2: Diabetic rates (type 2), Group 3: Diabetes rates treated with standard with lupeol at the dose of 25 mg/kg b.wt/day/orally for 30 days, and Group 4: Type 2 diabetic rats treated with metformin (50 mg/kg b.wt/day orally for 30 days. At the day of 30, the animals were anesthetized, blood from control and experimental were collected, sera were separated and used for the assessment of kidney function markers, and serum electrolytes were studied. Results: High-fat diet and sucrose-induced type 2 diabetic rats showed a significant increase in the levels of renal function markers (urea and creatinine) and serum electrolyte sodium (Na+) with concomitant decrease in the potassium level (K+). Post-treatment with the plant sterol and β-sitosterol could effectively normalize the renal biochemical profile as that of the control level. Conclusion: It is concluded from the present findings that lupeol has potential nephroprotective effects through by controlling renal biochemical profile.

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    Author(s) Name:

    R. Dharsan1 , V. Vishnu  Priya1 , R. Ponnulakshmi 2 , R. Gayathri 1 , K. Madhan1 , B. Shyamaladevi 1 , J. Selvaraj 1 *

    Affiliation(s) Name:

    1 Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India,

    2 Department of Central Research Laboratory, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. J. Selvaraj, Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, Tamil Nadu, India.

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    Author:

    R. Dharsan1 , V. Vishnu  Priya1 , R. Ponnulakshmi 2 , R. Gayathri 1 , K. Madhan1 , B. Shyamaladevi 1 , J. Selvaraj 1 *

    Title:Attenuation of diabetic nephropathy by a plant sterol lupeol: A biochemical analysis
    Journal:Drug Invention Today
    Vol(issue):12 (July)
    Year:2019
    Page No: (1402-1405)
  • Experimental Methods Keywords

    Methodology: Creatinine, Diabetic nephropathy,Nephroprotective effect, Urea
    Research Materials:Lupeol

Keywords

Creatinine Diabetic nephropathy Lupeol Nephroprotective effect Urea

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