Journal: Inter. J. of Chemical and Analytical Science

Article Id: JPRS-SDS-0000383
Title: Synthesis of Some Novel N- Acetyl Derivative of Sulpha Drugs and Their Biological Activities.
Category: Synthetic Drug Study
Section: Research Article
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  • Abstract

    Six Acetyl derivatives of some Sulpha drugs ( Sulfadoxine[1] , Sulfadimidine[2] , Sulphamethoxazole[3], Sulphadiazine[4], Dapsone[5] and Sulphamethaxazole [6] were synthesized. COCH3 group was introduced into heterocyclic framework of the Sulpha drugs. The derivatives (1A, 2A, 3A, 4A, 5A and 6A) were characterized by melting point, UV and IR spectroscopies, elemental analysis and Thin layer chromatography. The compounds were screened against Aspergillus niger, E.Coli and Staphylococcus aureus. Some of the derivatives were found to possess higher activities than the parent drugs. Toxicological studies were carried out by investigating the effect of administration of the parent drugs and derivatives on Alkaline phosphatase (ALP) activities of serum, liver and kidney of Albino rats. Overall, it was revealed that the derivatives exhibited lower toxicity on tested organs than the parent drugs.

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    Author(s) Name:

    Adedibu C. Tella,* and Joshua A. Obaleye

    Affiliation(s) Name:

    Department of Chemistry, P.M.B.1515, University of Ilorin, Ilorin, Nigeria.

    *Corresponding author.
    Adedibu C. Tella
    Department of Chemistry, P.M.B.1515, University of Ilorin, Ilorin, Nigeria.


    Received on: 20-06-2010; Revised on: 16-07-2010; Accepted on:15-08-2010

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    Author:

    Adedibu C. Tella,* and Joshua A. Obaleye

    Title:Synthesis of Some Novel N- Acetyl Derivative of Sulpha Drugs and Their Biological Activities.
    Journal:Inter. J. of Chemical and Analytical Science
    Vol(issue):1 (September)
    Year:2010
    Page No: (202-204)
  • Experimental Methods Keywords

    Methodology:Spectroscopy, Alkaline Phosphatase, Biological activity.
    Research Materials:Sulpha Drugs

Keywords

Sulpha Drugs Spectroscopy Alkaline Phosphatase Biological activity.

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