Journal: Inter. J. of Chemical and Analytical Science

Article Id: JPRS-PC-0000388
Title: Advances In HPLC Column Packing
Category: Pharmaceutical Chemistry
Section: Research Article
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    High Performance Liquid Chromatography (HPLC) is a highly improved form of column chromatography in which instead of a solvent being allowed to drip through a column under gravity, it is forced through under high pressures of up to 400 atmospheres(500-5000 p.s.i). The sensitivity and range of the technique depends on the choice of column and on the efficiency of the overall system. Column technology has seen great developments over the years. The transition from large porous particles and pellicular materials to small porous particles occurred in the early 1970s, when micro particulate silica gel (10 -mm dp) came into light and appropriate packing methods were developed. Monolithic columns are a promising alternative to packed columns in the future but much of the research is yet to be done. The use of CAPILLARY COLUMNS (4 mm) has increased in recent years, in part because small-diameter columns use much less solvent and provide higher sensitivity. While speaking of the future of packaging development, silica gel with chemically bonded phases will be around for a long time. The field is a promising one with great scope for research and development.

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    Author(s) Name:

    *Aastha Ahuja, Rahul Chib, Mukul Sonker, Geet Sethi, Shweta Gupta , Anju Hooda

    Affiliation(s) Name:

    Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR), University of Delhi Pushp vihar, sector-3, New Delhi-110017

    *Corresponding author.
    Aastha Ahuja
    Delhi Institute of Pharmaceutical Sciences and Research (DIPSAR),
    University of Delhi,Pushp vihar, sector-3, New Delhi-110017


    Received on: 20-05-2010; Revised on: 16-06-2010; Accepted on:15-07-2010

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    Author:

    *Aastha Ahuja, Rahul Chib, Mukul Sonker, Geet Sethi, Shweta Gupta , Anju Hooda

    Title:Advances In HPLC Column Packing
    Journal:Inter. J. of Chemical and Analytical Science
    Vol(issue):1 (September)
    Year:2010
    Page No: (205-207)
  • Experimental Methods Keywords

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    Research Materials:HPLC

Keywords

HPLC column packing Perfusion chromatography Monoliths.

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