Journal: Drug Invention Today

Article Id: JPRS-PC-00003912
Title: Structural comparison of glutathione S-transferase from human samples
Category: Pharmaceutical Chemistry
Section: Research Article
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    Introduction: Glutathione S-transferases (GST) are drug metabolizing enzymes. Various forms of GST and their chains have been reported. GST sequences from human and other species will be taken up, and comparative structure studies will be done to identify similarities and dissimilarities among alpha and omega subunit of GST. Materials and Methods: Sequence retrieval, structure modeling, and structure comparison were done in the samples of Chick, Rat, and Human. All the data were collected from the Swiss-Prot database and subjected to analysis. Results: A multiple sequence alignment involving all omega class sequences was obtaining, depicting a very high level of sequence convergence and thereby sequence similarity. Furthermore, there appears to be very negligible number of gaps in this alignment. In relation to GST omega, GST alpha classes of sequences are less similar. However, both the classes of GST in these selected species were found to be highly similar and therefore converged. Multiple structure comparison done using Mammoth-multitool resulted that the structures to adopting the same fold and architecture. Conclusion: This study thus shows the structural comparison of GST enzymes with human, rat, and chick samples.

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    Author(s) Name:

    Pavithra H. Dave, V. Vishnu Priya*, R. Gayathri

    Affiliation(s) Name:

    Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. V. Vishnu Priya, Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, Tamil Nadu, India.

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    Author:

    Pavithra H. Dave, V. Vishnu Priya*, R. Gayathri

    Title:Structural comparison of glutathione S-transferase from human samples
    Journal:Drug Invention Today
    Vol(issue):12 (August )
    Year:2019
    Page No: (1717-1720)
  • Experimental Methods Keywords

    Methodology:Alpha, Enzymes, Glutathione S-transferases, Omega, Sequencing
    Research Materials:Human samples

Keywords

Alpha Enzymes Glutathione S-transferases Omega Sequencing

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