Journal: Inter. J. of Chemical and Analytical Science

Article Id: JPRS-AC-0000393
Title: Estimation of Diacerein by UV Spectrophotometry in Bulk and formulation.
Category: Analytical Chemistry
Section: Research Article
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    Three simple, precise and economical UV methods have been developed for the estimation of Diacerein in bulk and pharmaceutical dosage form. In Absorbance maxima method, the absorbance maxima for Diacerin was found to be 256nm. In first order derivative method, the absorbance was measured at λmaxima = 266nm and λminima = 245nm and amplitude difference was measured for the respective concentration of standard and was plotted against concentration and regression equation was calculated. In area under curve method 244-264nm range was selected. Linearity for detector response was observed in the concentration range of 1- 11μg/ml for all three methods. The proposed methods were successfully applied for the determination of Diacerein in commercial pharmaceutical preparation. All three methods were validated statistically as per ICH guidelines.

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    Author(s) Name:

    Deshpande M. M.*, Gondane S. J , Mahajan .M. P, Deshpande A. S. ,Sawant S. D

    Affiliation(s) Name:

    Department of Pharmaceutical Analysis,STES’S Smt.Kashibai Navale College of Pharmacy, Kodhwa, Pune-411048, India

    *Corresponding author.
    Deshpande M.M.
    Department of Pharmaceutical Analysis,
    STES’S Smt.Kashibai Navale College of Pharmacy,
    Kodhwa, Pune-411048, India


    Received on: 21-11-2010; Revised on: 14-12-2010; Accepted on:01-01-2011

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    Author:

    Deshpande M. M.*, Gondane S. J , Mahajan .M. P, Deshpande A. S. ,Sawant S. D

    Title:Estimation of Diacerein by UV Spectrophotometry in Bulk and formulation.
    Journal:Inter. J. of Chemical and Analytical Science
    Vol(issue):2 (January)
    Year:2011
    Page No: (1-2)
  • Experimental Methods Keywords

    Methodology:Absorption Maxima Method , First order derivative Spectroscopy , Area under curve , UV spectroscopy.
    Research Materials:Diacerein

Keywords

Diacerein Absorption Maxima Method First order derivative Spectroscopy Area under curve UV spectroscopy.

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