Journal: Inter. J. of Chemical and Analytical Science

Article Id: JPRS-SDS-0000398
Title: Synthesis and Antimicrobial activity of Novel Pyrazolo [3,4-d] Pyrimidine derivatives
Category: Synthetic Drug Study
Section: Research Article
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    A series of new N-(2,5-dimethylphenyl)-7-methyl/7-methyl -3-oxo-5-phenyl-2,3-dihydro-5H-[1,3]thiazolo[3,2-a] pyrimidine-6-carboxamide have been synthesized by a three component (MCR) reaction involving N-(2,5-dimethylphenyl)-3-oxobutanamide,thioura and substituted benzaldehyde gives N-(2,5- dimethylphenyl)-6-methyl-4-phenyl-2-sulfanyl-1,2,3,4-tetrahydro pyrimidine-5-carboxamide which on reaction with dibromoethane /chloro acetylchloride respectively. The newly synthesized compounds were well characterized by elemental analysis, IR, 1H NMR and mass spectral studies. The newly synthesized compounds were screened for their antibacterial and antifungal activities and have exhibited moderate to excellent growth inhibition of bacteria and fungi. The results of such studies have been discussed in this paper.

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    Author(s) Name:

    Mukesh M. Chavda, Manish J. Solanki* and Jatin Upadhyay

    Affiliation(s) Name:

    Chemical Engineering Department, IDS, Nirma University, Ahmedabad
    Department of chemistry, Bahauddin Science college, Junagadh,
    Department of chemistry, M.V.M.Science and Homescience college Rajkot-360005, India.

    *Corresponding author.
    Manish J. Solanki
    Chemical Engineering Department, IDS,
    Nirma University, Ahmedabad,India.


    Received on: 20-05-2010; Revised on: 16-06-2010; Accepted on:15-07-2010

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    Author:

    Mukesh M. Chavda, Manish J. Solanki* and Jatin Upadhyay

    Title:Synthesis and Antimicrobial activity of Novel Pyrazolo [3,4-d] Pyrimidine derivatives
    Journal:Inter. J. of Chemical and Analytical Science
    Vol(issue):2 (May)
    Year:2011
    Page No: (15-17)
  • Experimental Methods Keywords

    Methodology:Synthesis and Antimicrobial activity
    Research Materials:Novel Pyrazolo [3,4-d] Pyrimidine derivatives

Keywords

N-(2 5-dimethylphenyl)-3-oxobutanamide Thiazolo[3 2-a]pyrimidinne-6-carboxamide; Antimicrobial activity.

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