Journal: Inter. J. of Chemical and Analytical Science

Article Id: JPRS-NPs-0000399
Title: Effect of ß-carotene from Chlorococcum humicola on biomarker enzymes, Lipid peroxidation and Antioxidants in B(a)P induced lung cancer
Category: Natural Products
Section: Research Article
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    Chlorococcum humicola, fresh water green algae accumulated high amounts of carotenoids with 50-60% of ß-carotene. ß-carotene inhibits tumour growth and suppresses benzo(a)pyrene induced lung cancer. Cancer induction was confirmed with marker enzymes (Gamma Glutamyl transpeptidase, 5’-Nucleotidase, Lactate dehydrogenase, and Adenosine deaminase). At various period of time interval, the biomarkers were assessed which shows the significant alteration on ß-carotene treatment. The levels of lipidperoxidation, enzymic antioxidants (Catalase, Super Oxide Dismutase, and Glutathione Peroxidase) and non-enzymic antioxidants (Reduced Glutathione, Vitamin A, Vitamin C, and Vitamin E) showed significant alterations compared with the control mice. The minimal lipid peroxidation and significant improvement of antioxidant status was found in the ß-carotene fed animals. The findings from overall data demonstrates that the animals post treated with ß-carotene from green algae C. humicola may prevent lung cancer and hence aid in establishing the chemopreventive effect when administered orally on lung cancer bearing mice.

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    Author(s) Name:

    Bhagavathy.S1 and Sumathi.P2

    Affiliation(s) Name:

    1 Research Scholar, Bharathiar University, Coimbatore, Tamilnadu, India.
    Asssistant Professor, Department of Biochemistry, Government Arts & Science college for Women, Krishnagiri, Tamilnadu, India.

     

    *Corresponding author.
    S.Bhagavathy,
    Assistant Professor,
    Mohamed sathak college of arts and science,Sholinganallur,
    Chennai,Tamilnadu,India,

    Received on: 20-02-2011; Revised on: 16-03-2011; Accepted on:15-04-2011

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    Author:

    Bhagavathy.S1 and Sumathi.P2

    Title:Effect of ß-carotene from Chlorococcum humicola on biomarker enzymes, Lipid peroxidation and Antioxidants in B(a)P induced lung cancer
    Journal:Inter. J. of Chemical and Analytical Science
    Vol(issue):2 (May)
    Year:2011
    Page No: (18-22)
  • Experimental Methods Keywords

    Methodology:biomarker enzymes, Lipid peroxidation , Antioxidants
    Research Materials:Chlorococcum humicola

Keywords

ß- carotene Biomarkers Antioxidants Lipid peroxidation Lung cancer Chlorococcum humicola

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