Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-000040
Title: Taste masked, orally disintegrating tablet containing microspheres for immediate release
Category: Pharmaceutics
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    The purpose of this study was to evaluate the potential of microspheres for taste masking when incorporated into orally disintegrating tablets. The microspheres were produced by emulsification solvent evaporation method using a model drug theophylline with a taste masking polymer. The solvent evaporation method was optimized to obtain microspheres with desirable characteristics. The microspheres were mixed with other excipients to form orally disintegrating tablets. Optimization using two factors and three levels using factorial approach was carried out. The microspheres were best formed using acetone in 40 ml liquid paraffin at 1600 rpm speed of stirring for 90 minutes. The yield was 85 ± 2 %, particle size was 315 ± 10.84 μ and the assay results showed entrapment of 93.77 ± 0.53 % drug. The tablets formed showed a hardness of 3 ± 0.5 kg/cm2 and in vitro disintegration of 25 ± 3 seconds. The in vitro drug release was 88 ± 4 % at the end of 30 minutes. In conclusion, microspheres can effectively mask the bitter taste of the active pharmaceutical ingredients in combination with the orally disintegrating tablets.

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  • About the authors and Affiliations

    Author(s) Name:

    Supriya Shidhaye*1, Sheetal Malke1 and Vilasrao Kadam1

    Affiliation(s) Name:

    1Bharati Vidyapeeth’s college of Pharmacy, Sector 8, CBD, Belapur, Navi Mumbai 400614, MH, India.

     
    For correspondence:

    Supriya Shidhaye,Bharati Vidyapeeth’s college of Pharmacy, Sector 8, CBD, Belapur,
    Navi Mumbai 400614, MH, India


    E-mail: supriya.shidhaye@yahoo.co.in


    Received on: 24-06-2008; Accepted on :28-09-2008

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    Author:

    Supriya Shidhaye*1, Sheetal Malke1 and Vilasrao Kadam1

    Title:Taste masked, orally disintegrating tablet containing microspheres for immediate release
    Journal:Journal of Pharmacy Research
    Vol(issue):1(2)
    Year:2008
    Page No: (225-229)
  • Experimental Methods Keywords

    Methodology:microspheres,solvent evaporation, taste masking
    Research Materials:heophylline

Keywords

Theophylline microspheres solvent evaporation taste masking orally disintegrating factorial design superdisintegrant.

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