Journal: Journal of Pharmacy Research

Article Id: JPRS-MPS-0000402
Title: Antioxidant mechanism(s) of protective effects of Fenugreek 4-hydroxyisoleucine and trigonelline enriched fraction (TF4H (28%)) Sugaheal® against copper-ascorbate induced injury to goat cardiac mit
Category: Mechanism / Pathway Study
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  • Abstract

    Sugaheal®, the 4-hydroxyisoleucine and trigonelline enriched fraction (TF4H (28%)) isolated from the seed of Trigonella foenum graecum (Linn.) is a well established antidiabetic drug. But the mechanism of its protection against diabetes is still unknown. Our experiments has revealed that this fraction (TF4H (28%)) Sugaheal® also possesses good antioxidant characteristics which is evident from its capacity to scavenge hydroxyl radical, superoxide anion radical, hydrogen peroxide and DPPH radical in chemically defined in vitro system.TF4H (28%) Sugaheal® also prevented the increase in lipid peroxidation level, protein carbonyl level and a concomitant decrease in reduced glutathione level in goat heart mitochondria against Cu-ascorbate induced oxidative stress in an in vitro system. These above facts are also confirmed by its inhibition of increase in Mn-SOD activity and induction of glutathione reductase (the reduced glutathione synthesizing enzyme) and Krebs cycle enzyme activity, which makes its antioxidant phenomenon.

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    Author(s) Name:

    Mousumi Dutta 1,2, Arnab Kumar Ghosh1, Vishwaraman Mohan3, Prachi Shukla4, Vinod Rangari4, Aindrila Chattopadhyay2,Tridib Das5, Debojit Bhowmick5 and Debasish Bandyopadhyay1#*

    Affiliation(s) Name:

    1Oxidative Stress and Free Radical Biology Laboratory, Department of Physiology, University of Calcutta, University College of Science and Technology, 92, APC Road, Kolkata 700 009, INDIA. #Principal Investigator, Centre with Potential for Excellence in Particular Area (CPEPA), University of Calcutta, University College of Science and Technology, 92, APC Road, Kolkata 700 009, India.
    2Department of Physiology, Vidyasagar College, Kolkata 700 006, India.
    3 CEO, Indus Biotech Pvt. Ltd. 1, Rahul Residency, Off. Salunke Vihar Road, Kondhwa, Pune, Maharashtra - 411 048, India
    4S.L.T. Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (Central University), Koni, Bilaspur-495 009 (CG), India.
    5Acharya Prafulla Chandra Sikhsha Prangan, University of Calcutta, JD-2, Sector-III, Salt Lake City, Kolkata 700098, India.

    *Corresponding author.
    Dr. Debasish Bandyopadhyay
    Oxidative Stress and Free Radical Biology Laboratory,
    Department of Physiology, University of Calcutta
    University College of Science and Technology
    92 APC Road, Kolkata 700 009, India.


    Received on:21-04-2014; Revised on: 25-05-2014; Accepted on:10-06-2014

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    Author:

    Mousumi Dutta 1,2, Arnab Kumar Ghosh1, Vishwaraman Mohan3, Prachi Shukla4, Vinod Rangari4, Aindrila Chattopadhyay2,Tridib Das5, Debojit Bhowmick5 and Debasish Bandyopadhyay1#*

    Title:Antioxidant mechanism(s) of protective effects of Fenugreek 4-hydroxyisoleucine and trigonelline enriched fraction (TF4H (28%)) Sugaheal® against copper-ascorbate induced injury to goat cardiac mit
    Journal:Journal of Pharmacy Research
    Vol(issue):8 (June)
    Year:2014
    Page No: (798-811)
  • Experimental Methods Keywords

    Methodology:scavenge hydroxyl radical, superoxide anion radical, hydrogen peroxide and DPPH radical
    Research Materials:Trigonelline

Keywords

Sugaheal® Trigonelline 4-hydroxy isoleucine Cu-ascorbate Cardiac mitochondria.

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