Journal: Drug Invention Today

Article Id: JPRS-P col-00004119
Title: Anti-inflammatory activity of Murraya koenigii – An in vitro study
Category: Pharmaceutics
Section: Research Article
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    Background: In the ancient time, many naturally occurring plants played an important role in discovery in many therapeutic agents. It has been shown to have beneficial role such as therapeutic uses include beneficial effects on the cardiovascular system, antibiotic, anticancer, anti-inflammatory, and hypoglycemic effects. Objective: The study was designed to evaluate the anti-inflammatory effect of Murraya koenigii leaf ethanolic extract by in vitro analysis. Materials and Methods: The plant leaf powder was loaded into Soxhlet extractor and subjected to extraction with ethanol. After extraction, the solvent was distilled off and the extracts were concentrated on water bath to a dry residue and kept in a desiccator. Results: Protein denaturation is a process, in which proteins lose their tertiary structure and secondary structure by the application of external stress or compound, such as strong acid or base, a concentrated inorganic salt, an organic solvent, or heat. Denaturation of proteins is a well-documented cause of inflammation. As part of the investigation on the mechanism of the anti-inflammation activity, ability of plant extract to inhibit protein denaturation was studied. It was effective in inhibiting heat-induced albumin denaturation. Maximum inhibition of 88% was observed at 500 µg/ml. Aspirin, a standard anti-inflammatory drug showed the maximum inhibition of 99% at the concentration of 100 µg/ml compared with control. Conclusions: Results indicate that the ethanol extracts of M. koenigii possess anti-inflammatory properties. These activities may be due to the strong occurrence of polyphenolic compounds such as alkaloids, flavonoids, tannins, steroids, and phenols. The extract fractions serve as free radical inhibitors or scavenger or acting possibly as primary oxidants and inhibited the heat-induced albumin denaturation.

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    Author(s) Name:

    Kadambari Sriram1 , V. Vishnupriya1 , R. Ponnulakshmi 2 , R. Gayathri 1 , K. Madhan1 , B. Shyamaladevi 1 , J. Selvaraj 1 *

    Affiliation(s) Name:

    1 Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India,

    2 Department of Central Research Laboratory, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. J. Selvaraj, Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, Tamil Nadu, India.

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    Author:

    Kadambari Sriram1 , V. Vishnupriya1 , R. Ponnulakshmi 2 , R. Gayathri 1 , K. Madhan1 , B. Shyamaladevi 1 , J. Selvaraj 1 *

    Title:Anti-inflammatory activity of Murraya koenigii – An in vitro study
    Journal:Drug Invention Today
    Vol(issue):11 (October )
    Year:2019
    Page No: (2384-2386)
  • Experimental Methods Keywords

    Methodology:Anti-inflammatory activity, Ethanol extract, In vitro analysis
    Research Materials: Murraya koenigii

Keywords

Anti-inflammatory activity Ethanol extract In vitro analysis Murraya koenigii

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