Journal: Drug Invention Today

Article Id: JPRS-CA-00004221
Title: Determination of the main component presumably as antidiabetes contained in the ethyl acetate fraction of banana Fe’i (Musa troglodytarum L.) using liquid chromatography–mass spectrometry
Category: Compounds ( Natual and Synthetic ) Analysis
Section: Research Article
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    Objective: Fe’i banana or “banana sticks sky” or “pisang tongkat langit” (Musa troglodytarum L.) traditionally and been reported to have antidiabetes activity. The previous research stated that the administration of ethyl acetate fraction from the sky stick bananas could reduce blood glucose levels in mice induced by alloxan. This study aimed to isolate and determine a major chemical compound from ethyl acetate fraction of Fe’i banana fruit. Materials and Methods: The material was macerated using ethanol 70% then fractionation by liquid-liquid chromatography method using n-hexane, ethyl acetate, and water. The ethyl acetate fraction was subfractionated by classical column chromatography and preparative thin-layer method and ensuring isolate purity using two-way thin-layer chromatography (TLC). Compound identification methods include organoleptic, TLC with specific spotting appearance, infrared (IR) spectrophotometry, and mass spectroscopy. From the study, four isolates were produced, but MT2 isolates had more results and were possible to be identified. Results and Discussion: The results of group identification showed that MT2 isolates were thought to be steroid group compounds. IR spectrophotometry results showed that isolates had functional groups C-O (aldehyde), C-O (carboxylate/ alcohol), C-H (alkana), C-H bend, C = C, C = O (aldehyde), C-H and O-H, and mass spectroscopy results that the isolate has a molecular weight of 507.1436 m/z. Conclusion: It was found that the main component in the ethyl acetate fraction of banana Fe’i was a compound with molecular formula C31 H23 O7 , C38 H19 O2 , or C24 H27 O12 which was similar to breynioside B.

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    Author(s) Name:

    Resmi Mustarichie1 *, Fikri Dwi Alminda1 , Dolih Gozali 2 , Moelyono Moektiwardoyo3

    Affiliation(s) Name:

    1 Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jawa Barat 45363, Indonesia,

    2Department of Pharmaceutics, Faculty of Pharmacy, Universitas Padjadjaran, Jawa Barat 45363, Indonesia,

    3 Department of Biology Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jawa Barat 45363, Indonesia

    *Corresponding author: Resmi Mustarichie, Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Jawa Barat 45363, Indonesia.

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    Author:

    Resmi Mustarichie1 *, Fikri Dwi Alminda1 , Dolih Gozali 2 , Moelyono Moektiwardoyo3

    Title:Determination of the main component presumably as antidiabetes contained in the ethyl acetate fraction of banana Fe’i (Musa troglodytarum L.) using liquid chromatography–mass spectrometry
    Journal:Drug Invention Today
    Vol(issue):12 (October)
    Year:2019
    Page No: (2259-2263)
  • Experimental Methods Keywords

    Methodology:Liquid chromatography–mass spectrometry
    Research Materials:banana Fe’i (Musa troglodytarum L.)

Keywords

banana sticks sky Breynioside B Fe’i banana Liquid chromatography–mass spectrometry Musa troglodytarum

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