Journal: Journal of Pharmacy Research

Article Id: JPRS-PHDRS-0000428
Title: In vitro and In vivo anti-cancer activity of leaves of Plumeria alba Linn.
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
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    The anti-cancer activities of different extracts of leaves of Plumeria alba Linn (Apocynaceae) were investigated for invitro cytotoxicity by the trypan blue exclusion method using DLA and L929 cell lines. The methanolic extract showed potent in vitro anti-cancer activity, then the extract screened for invivo anticancer activity using survival time, heamatological and histopathologial studies in ascitic fluid in mice. The potency of the extracts was compared with standard 5-flurouracil (20 mg/kg i.p.). The methanolic extract was also found to increase the lifespan, improvement in the haematological parameters like haemoglobin content, red blood cell and white blood cell count of the tumour bearing mice have also been observed. Histopathological studies have revealed a reduction in the mitotic activity and the appearance of vacuolization, necrosis in the treated tumour cells. The results of the present study suggest that methanolic extract of Plumeria alba has an anti-cancer activity.

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    Author(s) Name:

    Ramalingam Radha 1* and T. Sivakumar 2

    Affiliation(s) Name:

    *1Department of pharmaceutical sciences, college of pharmacy, Madras Medical College, Chennai – 600 003.
    2Nandha college of pharmacy, Erode, Tamil Nadu, India


    For correspondence: R.Radha,S-5 Block II, Ganesh Apartments, No.45,Thomas Street, Kadaperi, Tambaram, Chennai- 600045. Tamil Nadu,India


    Received on:11-08-2008; Accepted on :04-12-2008

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    Author:

    Ramalingam Radha 1* and T. Sivakumar 2

    Title:In vitro and In vivo anti-cancer activity of leaves of Plumeria alba Linn.
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (February)
    Year:2009
    Page No: (203-207)
  • Experimental Methods Keywords

    Methodology:Anticancer, Cytotoxicity
    Research Materials:Plumeria alba

Keywords

Plumeria alba Anticancer Cytotoxicity

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