Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000429
Title: Design and development of mucoadhesive microcapsules of glipizide formulated with gum karaya
Category: Pharmaceutics
Section: Research Article
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    Mucoadhisive microcapsules are proposed for the antidiabetic drug glipizide, to obtain controlled release. Glipizide microcapsules with a coat consisting of alginate and gum karaya were prepared by employing ionic gelation process and emulsification ionotropic gelation process. The microcapsules were evaluated for flow properties, Carr’s index, hausner ratio, microencapsulation efficiency, drug release characteristics, surface characteristics; compatibility studies mucoadhesive properties and in-vivo hypoglycemic activity. As hausner ratio was less than 1.25 and Carr’s index values were less than 15 from both the methods, hence they were found to be free flowing. Sharp endothermic peaks were noticed from the microcapsules formulated with two different techniques at 215oC indicating the compatibility between the drug and the polymer gum karaya. Glipizide release from the microcapsules was slow and followed zero order kinetics (r > 0.98) and followed non–fickian (n value 0.5 to 1) release and depended on the coat: core ratio and the method employed in the preparation of microcapsules. Among the two methods emulsification ionotropic gelation method was found to be more suitable for slow and complete release of glipizide over a long period of time. These microcapsules exhibited good mucoadhesive property in the in-vitro wash-off test. In vivo testing into rabbits demonstrated significant hypoglycemic effect of glipizide.

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  • About the authors and Affiliations

    Author(s) Name:

    Raparla Rama Krishna*1, Talasila Eswara Gopala Krishna Murthy1 and

    V Himabindu2

    Affiliation(s) Name:

    *1Bapatla College of Pharmacy, Bapatla, Andhra Pradesh, India.
    2Dept of Biotechnology, J. N. T. University, Hyderabad, Andhra Pradesh, India.


    For correspondence:Raparla Rama Krishna, Bapatla College of Pharmacy, Bapatla, Andhra Pradesh, India.

    Received on:19-08-2008; Accepted on :23-12-2008

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    Author:

    Raparla Rama Krishna*1, Talasila Eswara Gopala Krishna Murthy1 and

    V Himabindu2

    Title:Design and development of mucoadhesive microcapsules of glipizide formulated with gum karaya
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (February)
    Year:2009
    Page No: (208-214)
  • Experimental Methods Keywords

    Methodology:ionic gelation technique, emulsification gelation technique.
    Research Materials:Glipizide

Keywords

Glipizide gum karaya ionic gelation technique emulsification gelation technique.

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