Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-000043
Title: Peptic ulcer and its management
Category: Pharmaceutics
Section: Review Article
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    Ulceration of gastro-intestinal mucosa is caused by disruption of normal balance of corrosive effect of gastric acid and the protective effect of mucus on gastric epithelial cells. The major cause of ulcer is increased gastric secretions, which may be further aggravated by factors including NSAIDs, impaired production of somatostatins, Helicobacter pylori infection, by stress and dietary habits. Up to 80-90% of ulcers has been associated with H. pylori infection in the stomach. The parietal cells in the stomach secrete hydrochloric acid regulated by the protein H+/K+-ATPase also called proton pump. Acid secretion is also regulated by hormones such as gastrin, chemicals like acetylcholine and histamine. Acid neutralization was recognized as an effective treatment, however with the understanding of pathogenesis of peptic ulcer, treatment has become more effective. One approach for treating ulcer is to block the proton pump by using proton pump inhibitors like omeprazole, lansoprazole. In another approach, blocking of regulatory molecules that stimulate acid secretion like acetylcholine, histamine and gastrin either with anticholinergics or H2 receptor antagonist such as ranitidine, famotidine is effective. H.pylori infection can be eradicated using amoxycillin, clarithromycin, metronidazole or tetracycline. Combination therapy helps in complete eradication of peptic ulcer; one of the combinations, approved by USFDA is omeprazole with clarithromycin. Gastro retentive dosage forms may prove beneficial as they exhibit a prolonged gastric residence time and act locally and systemically.

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  • About the authors and Affiliations

    Author(s) Name:

    Vinay Pandit*1,Sarasija Suresh1 and Hemanth Joshi1

    Affiliation(s) Name:

    1Department of Pharmaceutics, Al- Ameen College of Pharmacy, Bengalooru, 560027, India.

    For correspondence:

    Vinay Pandit,Department of Pharmaceutics, Al- Ameen College of Pharmacy, Bengalooru, 560027, India


    Received on: 07-05-2008; Accepted on :22-08-2008

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    Vinay Pandit*1,Sarasija Suresh1 and Hemanth Joshi1

    Title:Peptic ulcer and its management
    Journal:Journal of Pharmacy Research
    Vol(issue):1 (Oct-December 2008)
    Page No: (245-252)
  • Experimental Methods Keywords

    Methodology:ITS MANAGEMENT
    Research Materials:Peptic Ulcer


Peptic Ulcer Management

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