Journal: Drug Invention Today

Article Id: JPRS-MSNS-00004303
Title: Combinatory effect of embelin with antibiotics against Staphylococcus aureus
Category: Microbiological Study (on Natural/ Synthetic drug)
Section: Research Article
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    Aim: The study aims to evaluate the combinatory effect of embelin with antibiotics against Staphylococcus aureus. Materials and Methods: Embelin was isolated from Embelia ribes. The combinatory antibacterial effect of embelin along with antibiotics against S. aureus was determined using disc diffusion assay. Results and Discussion: The antibacterial study showed that 4 mg/disc of embelin enhanced antibacterial activities in four of eight standard antibiotics against S. aureus. Nalidixic acid in combination with embelin depicted the highest fold increase in area which accounts for 98.61%. Combination with ciprofloxacin, vancomycin, and tetracycline resulted in fold increase in area for 16.19%, 6.38%, and 5.91%, respectively. Conversely, antagonist interaction occurred for gentamicin and embelin combination against S. aureus. At the same time, there is no synergetic antibacterial effect observed with other tested antibiotics against S. aureus. Conclusion: The results suggest that the use of embelin in combination with antibiotics may be microbiologically useful in therapy against S. aureus.

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    Author(s) Name:

    Nurul Azima Mazlan1 , Shazalyana Azman2 , Nurin Fatini Ghazali 1 , Puteri Zarith Sofea Yusri 1 , Hikmah Mohd Idi 1 , Masitah Ismail 3 , Mahendran Sekar1 *

    Affiliation(s) Name:

    1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Health Sciences, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh, Malaysia,

    2 Department of Bioengineering and Technology Section, Universiti Kuala Lumpur Malaysian Institute of Chemical and Bioengineering Technology, Alor Gajah, Melaka, Malaysia,

    3 Department of Preclinical, Faculty of Medicine, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh, Malaysia

    *Corresponding author: Dr. Mahendran Sekar, Faculty of Pharmacy and Health Sciences, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh, Malaysia.

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    Author:

    Nurul Azima Mazlan1 , Shazalyana Azman2 , Nurin Fatini Ghazali 1 , Puteri Zarith Sofea Yusri 1 , Hikmah Mohd Idi 1 , Masitah Ismail 3 , Mahendran Sekar1 *

    Title:Combinatory effect of embelin with antibiotics against Staphylococcus aureus
    Journal:Drug Invention Today
    Vol(issue):12 (November [ Special Issue 1])
    Year:2019
    Page No: (18-20)
  • Experimental Methods Keywords

    Methodology:Antibacterial activity
    Research Materials:Embelin

Keywords

Antagonism Antibacterial Disc diffusion method Embelin Staphylococcus aureus Synergism

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