Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000434
Title: Development and evaluation of sustained release matrix tablet using hydrophilic gums as release modifier
Category: Pharmaceutics
Section: Research Article
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    The objective of the present study was to design oral sustained drug delivery system for freely water-soluble drug, metoprolol succinate using hydrophilic gums. The gums selected were karaya gum and guar gum and their combination. To study the rheological synergism between karaya gum and guar gum in different ratio (0:10-10:0) was determined and the combination having highest viscosity (6:4) was used for matrix tablet formulation. Nine batches were prepared by using karaya gum and guar gum in 15%, 20% and 25% concentration of the total weight of tablet. Matrix tablets were prepared by wet granulation method and the prepared tablets were evaluated for weight variation, content uniformity, percentage friability, hardness, thickness, swelling index and in vitro dissolution studies. All the formulation showed compliance with pharmacopoeial standards. Formulation F1, F6 and F7 showed sustained release of drug for 12 hrs with 97.65%, 98.23% and 96.98% respectively. The optimized formulation was subjected to accelerated stability studies for one month at temperature of 400C and relative humidity of 75%. and showed physical stability and stability with respect to drug release pattern. The kinetic treatment showed that the formulations follow zero order with release exponent (n) was 0.8275, 0.9633 and 0.8079 for formulation F1, F6 and F7. So the combination of karaya gum and guar gum shows better prosperity for preparation of sustained release tablets as compare to individual gums.

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  • About the authors and Affiliations

    Author(s) Name:

    V. N. Deshmukh*1, D. M.Sakarkar1 and S. P. Singh1

    Affiliation(s) Name:

    *1Sudhakarrao Naik Institute of Pharmacy, Pusad, Dist- Yavatmal (M.S.), 445204,India

    For correspondence:

    V.N. Deshmukh ,Sudhakar Rao Naik Institute of Pharmacy, Pusad, Dist- Yavatmal (M.S.),
    445204,India

    Received on:12-08-2008; Accepted on :24-12-2008

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    Author:

    V. N. Deshmukh*1, D. M.Sakarkar1 and S. P. Singh1

    Title:Development and evaluation of sustained release matrix tablet using hydrophilic gums as release modifier
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (February)
    Year:2009
    Page No: (226-229)
  • Experimental Methods Keywords

    Methodology:Development and evaluation
    Research Materials:Matrix tablet

Keywords

Matrix tablet Hydrophilic gum Metoprolol succinate Karaya gum Guar gum.

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