Journal: Journal of Pharmacy Research

Article Id: JPRS-PCS-0000435
Title: Enhancement of solubility and dissolution rate of Rifampicin by melt granulation technique
Category: Pharmaceutics
Section: Research Article
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    This work describes a melt granulation technique to improve the solubility and dissolution characteristics of a poorly water-soluble drug, rifampicin. Melt granulation technique is a process by which pharmaceutical powders are efficiently agglomerated by a meltable polymers and surfactants. The advantage of this technique compared to a conventional granulation is that no water or organic solvents is needed. Because there is no drying step, the process is less time consuming and uses less energy than wet granulation. Granules were prepared by using polymer like different grades of polyethylene glycol and surfactantlike different grades of poloxomers. The granules were characterized using powder XRD, DSC and FTIR techniques. A significant enhancement in the in vitro dissolution profiles of the melt granules was observed compared to the pure drug and drug excipient physical mixtures. Besides the remarkable enhancement of drug dissolution rate of the granulates in comparison to physical mixtures and pure drug, no significant differences were found between the dissolution profiles of the melted granulates containing lactose or crospovidone. XRD data confirmed crystalline drug in the melted granules. DSC results indicated change in internal energy of Rifampicin with polymers and surfactant in the melted granulated. In conclusion, the results of this work suggest that melt granulation is a useful technique to enhance the solubility and dissolution rate of poorly water-soluble drugs, such as, Rifampicin.

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    Author(s) Name:

    Yadav VB*1, Nigute AB1, Yadav AV1 and Bhise SB1

    Affiliation(s) Name:

    *1Department of Biopharmaceutics, Govt.College of Pharmacy, Vidya nagar, Karad,Dist-Satara (MS), India


    For correspondence:Venkat B Yadav.,Department of Biopharmaceutics, Govt.College of Pharmacy, Vidya nagar, Karad, Dist-Satara (MS), India


    Received on:08-08-2008; Accepted on :18-12-2008

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    Author:

    Yadav VB*1, Nigute AB1, Yadav AV1 and Bhise SB1

    Title:Enhancement of solubility and dissolution rate of Rifampicin by melt granulation technique
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (February)
    Year:2009
    Page No: (230-235)
  • Experimental Methods Keywords

    Methodology:Enhancement of solubility and dissolution rate
    Research Materials:Rifampicin

Keywords

Rifampicin surfactants melts granulation Dissolution enhancement polyethylene glycol.

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