Journal: Drug Invention Today

Article Id: JPRS-Pcol-00004397
Title: Protective role of Maha Vallathy Leghiyam on 4-nitroquinoline-1-oxide-induced experimental oral carcinogenesis
Category: Pharmacology
Section: Research Article
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    Introduction: The aims of this current study were to examine the effects of Maha Vallathy Leghiyam (MVL) on changes in lipid peroxidation (LPO) status of malondialdehyde (MDA) generation. MDA is a major LPO product that is mutagenic and tumorigenic. The potential protective effect of MVL was 4-nitroquinoline-1-oxide (4NQO)-induced rats. Materials and Methods: The male Wistar rats were subjected to the 50 ppm of carcinogen 4NQO through drinking water, and the activity of MVL against the carcinogenic cells was studied through LPO and lipid hydroperoxides (LOOH) hydroxyl radical formation. Results: The obtained result was visualized as an increase in the expression of the LPO and hydroxyl radicals in the serum of control and experimental group of animals, these results were associated with the generation of MDA. The administration of MVL (100 mg/kg body weight) protects the generation of LPO products, thereby proves its anticancer potential. Conclusions: The administration of MVL has caused significant decrease activities of LPO and LOOH, these aspects suggesting the protective nature of MVL against the carcinogenic nature of water-soluble carcinogen 4NQO by efficiently decreasing the oxidative damage.

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    Author(s) Name:

    G. Priyanka1,2 , Kayalvizhi Elumalai 1 *

    Affiliation(s) Name:

    1Department of Physiology, Meenakshi Medical College Hospital and Research Institute, Kanchipuram, Tamil Nadu, India,

    2Department of Physiology, Saveetha Medical College and Hospital, Ponnamalle High Raod, Thandalam, Chennai, Tamil Nadu, India

    *Corresponding author: Dr. Kayalvizhi Elumalai, Department of Physiology, Meenakshi Medical College Hospital and Research Institute, Kanchipuram, Tamil Nadu, India.

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    Author:

    G. Priyanka1,2 , Kayalvizhi Elumalai 1 *

    Title:Protective role of Maha Vallathy Leghiyam on 4-nitroquinoline-1-oxide-induced experimental oral carcinogenesis
    Journal:Drug Invention Today
    Vol(issue):11 (November )
    Year:2019
    Page No: (2996-2999)
  • Experimental Methods Keywords

    Methodology:Protective role
    Research Materials: Maha Vallathy Leghiyam

Keywords

4-nitroquinoline-1-oxide Lipid hydroperoxides Lipid peroxidation Maha Vallathy Leghiyam Malondialdehyde Rats

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