Journal: Journal of Pharmacy Research

Article Id: JPRS-PHDRS-0000442
Title: Study the Effect of Phytochemical Constituents of Piper betel Leaves Extracts on Liver Disorders by in vivo Model
Category: Pharmacognosy and Herbal Drugs related study
Section: Research Article
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    An in vivo study was conducted to evaluate the hepatoprotective activity of ethanolic extracts of Piper betel leaves. Liver damage was induced in male Wistar rats weighed 150-200 gm by administering CCl4 (2ml/kg i.p) regularly for 10 days and tissue damage was noted by various biochemical parameters like serum glutamate oxaloacetate transaminase (SGOT), serum glutamate Pyruvate transaminase (SGPT), Alkaline Phosphatase (ALP), Acid Phosphatase (ACP), Lipid peroxidation, Level of antioxidant enzyme like catalase (CAT), Superoxide dismutase (SOD), Glutathione (GSH) in liver. Ethanolic extract of piper betel 100 mg/kg and 200 mg/kg i.p administered regularly for 10 days and compared with a control group silymarin (25 mg/kg i.p.). A significant reduction in serum SGOT, SGPT, ALP, ACP, lipid peroxidation and improvement in CAT, SOD, GSH, MDA level in the liver were observed when compared with CCl4 administered rats. Piper betel leaves extract (PBLE) was able to protect the liver against the oxidative damage produced by CCl4.

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    Author(s) Name:

    *Ashish Manigauha 1, Sunita Patel1, Huma Ali 2, A. Chandy and M. Uma Maheshwari 3

    Affiliation(s) Name:

    *1 NRI Institute of Pharmacy, Sajjan Singh Nagar, Raisen road, Bhopal - 462021, India
    2 Deptt of Research, Jawaharlal Nehru Cancer Hospital & Research Center, Bhopal. India
    3 School of Pharmacy, Chouksey Engineering College, Bilaspur, India.
    4 College of Pharmacy, SRIPMS, Coimbatore, Tamilnadu. India


    For correspondence:Ashish Manigauha,Department of Pharmacology and Phytochemistry,  NRI Institute of Pharmacy, Sajjan Singh Nagar, Raisen road, Bhopal - 462021, India


    Received on:09-08-2008; Accepted on :10-01-2009

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    Author:

    *Ashish Manigauha 1, Sunita Patel1, Huma Ali 2, A. Chandy and M. Uma Maheshwari 3

    Title:Study the Effect of Phytochemical Constituents of Piper betel Leaves Extracts on Liver Disorders by in vivo Model
    Journal:Journal of Pharmacy Research
    Vol(issue):2 (March)
    Year:2009
    Page No: (353-356)
  • Experimental Methods Keywords

    Methodology:hepatotoxicity, biochemical, antioxidant
    Research Materials:Piper betel

Keywords

Phytochemical Piper betel hepatotoxicity biochemical antioxidant

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